N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP

Stable Identifier
R-HSA-176669
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sulfonation of the xenobiotic N-hydroxy-2-acetylaminofluorene converts it to a potent carcinogen. SULT1A2 (Glatt 2000) and SULT1C1 and 1C2 (Sakakibara et al. 1998) catalyze this reaction.

Literature References
PubMed ID Title Journal Year
9852044 Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene

Sakakibara, Y, Yanagisawa, K, Katafuchi, J, Ringer, DP, Takami, Y, Nakayama, T, Suiko, M, Liu, MC

J Biol Chem 1998
11154739 Sulfotransferases in the bioactivation of xenobiotics

Glatt, H

Chem Biol Interact 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sulfotransferase activity of SULTs active on NH2AAF [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created
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