Reactome | HNMT transfers CH3 group from AdoMet to Hist

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HNMT transfers CH3 group from AdoMet to Hist Show undefined attributes

authored	[InstanceEdit:175989] Jassal, B, 2006-02-27 14:54:40
catalystActivity	[CatalystActivity:175990] histamine N-methyltransferase activity of HNMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:175989] Jassal, B, 2006-02-27 14:54:40
crossReference	[DatabaseIdentifier:12667941] RHEA:19302 [DatabaseIdentifier:9925937] RHEA:19302
dbId	175993
displayName	HNMT transfers CH3 group from AdoMet to Hist
edited	[InstanceEdit:6784185] Jassal, Bijay, 2015-06-18
eventOf	[Pathway:R-HSA-70921] Histidine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9970023] AOC1 dimer oxidizes MeHist - Homo sapiens
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-175992] Hist [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5694134] Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway [LiteratureReference:5694101] Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons [LiteratureReference:5694088] The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics
maxDepth	1
modified	[InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
name	HNMT transfers CH3 group from AdoMet to Hist histamine + S-adenosyl-L-methionine => H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine Histamine is deactivated by N-methylation
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-175991] MeHist [cytosol]
precedingEvent	[Reaction:R-HSA-977301] Histidine is decarboxylated to histamine - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-175993
summation	[Summation:5694105] Histamine (Hist) plays important biological roles in cell-to...
updateTrackers	[UpdateTracker:9928448] Update Tracker - [Reaction:175993] HNMT transfers CH3 group from AdoMet to Hist - v91:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9928448] Update Tracker - [Reaction:175993] HNMT transfers CH3 group from AdoMet to Hist - v91:[removeOutput]
(hasEvent)	[Pathway:R-HSA-70921] Histidine catabolism
(precedingEvent)	[Reaction:R-HSA-9970023] AOC1 dimer oxidizes MeHist

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