Histamine (Hist) plays important biological roles in cell-to...

created [InstanceEdit:5694122] Jassal, Bijay, 2015-05-21
dbId 5694105
displayName Histamine (Hist) plays important biological roles in cell-to...
schemaClass Summation
text Histamine (Hist) plays important biological roles in cell-to-cell communication via by binding to histamine receptors and its local action is terminated primarily by methylation. Histamine is inactivated principally by two enzymes: histamine N-methyltransferase (HNMT) and diamine oxidase. HNMT uses the methyl donor AdoMet, methylates Hist to form methylhistamine (MetHist) (Yamauchi et al. 1994). The common polymorphism T105I correlates with high (T) or low (I) activity phenotypes (Horton et al. 2001, Rutherford et al. 2008).
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