Reactome | chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols

Schema > Reaction > Entries

chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols Show undefined attributes

authored	[InstanceEdit:197113] D'Eustachio, P, 2007-04-30 14:19:38
catalystActivity	[CatalystActivity:174759] lipoprotein lipase activity of GPIHBP1:HSPG:LPL dimer [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:174717] D'Eustachio, P, 2006-02-20 17:46:54
dbId	174757
displayName	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
edited	[InstanceEdit:174830] D'Eustachio, P, 2006-02-20 18:35:05
eventOf	[Pathway:R-HSA-8963901] Chylomicron remodeling - Homo sapiens
followingEvent	[Reaction:R-HSA-174690] TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III - Homo sapiens
input	[Complex:R-HSA-174697] chylomicron [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:174794] Comparison of apolipoprotein C-II-deficient triacylglycerol-rich lipoproteins and trioleoylglycerol/phosphatidylcholine-stabilized particles as substrates for lipoprotein lipase [LiteratureReference:174613] Human lipoprotein lipase: relationship of activity, heparin affinity, and conformation as studied with monoclonal antibodies [LiteratureReference:174715] Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein [LiteratureReference:174641] Lipoprotein lipase-mediated uptake of lipoprotein in human fibroblasts: evidence for an LDL receptor-independent internalization pathway [LiteratureReference:174821] Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
orthologousEvent	[Reaction:R-SSC-174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - Sus scrofa [Reaction:R-BTA-174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - Bos taurus [Reaction:R-CFA-174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - Canis familiaris [Reaction:R-RNO-174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - Rattus norvegicus [Reaction:R-MMU-174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - Mus musculus
output	50 × [SimpleEntity:R-ALL-174675] DAGs [extracellular region] 50 × [SimpleEntity:R-ALL-174602] LCFAs [extracellular region] [Complex:R-HSA-174798] TG-depleted chylomicron [extracellular region]
precedingEvent	[Reaction:R-HSA-174660] nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron - Homo sapiens [Reaction:R-HSA-8857928] GPIHBP1 binds HSPG:LPL dimer - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-174621] Positive regulation by 'APOC2 [extracellular region]' [NegativeRegulation:R-HSA-174677] Negative regulation by 'APOC3 [extracellular region]' [PositiveRegulation:R-HSA-174695] Positive regulation by 'APOA5 [extracellular region]'
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174757
summation	[Summation:174793] Lipoprotein lipase dimers (LPL:LPL) are tethered to heparan ...
updateTrackers	[UpdateTracker:9788474] Update Tracker - [Reaction:174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - v42:[modifyText] [UpdateTracker:9788258] Update Tracker - [Reaction:174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788474] Update Tracker - [Reaction:174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - v42:[modifyText] [UpdateTracker:9788258] Update Tracker - [Reaction:174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-8963901] Chylomicron remodeling
(precedingEvent)	[Reaction:R-HSA-174690] TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III

Cite Us!