Reactome | Formation of Processive Complex on the C-strand of the telomere

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Formation of Processive Complex on the C-strand of the telomere Show undefined attributes

authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
dbId	174448
displayName	Formation of Processive Complex on the C-strand of the telomere
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
eventOf	[Pathway:R-HSA-174411] Polymerase switching on the C-strand of the telomere - Homo sapiens
followingEvent	[Reaction:R-HSA-174444] Formation of C-strand Okazaki fragments - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input	[Complex:R-HSA-68450] DNA Polymerase delta tetramer [nucleoplasm] [Complex:R-HSA-174450] RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9668885] DNA polymerase ? stalls on telomeric lagging strand templates independently from G-quadruplex formation [LiteratureReference:69076] Mechanism of elongation of primed DNA by DNA polymerase delta, proliferating cell nuclear antigen, and activator 1. [LiteratureReference:69070] Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA.
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Formation of Processive Complex on the C-strand of the telomere
negativePrecedingEvent	[NegativePrecedingEvent:9766491] Futile Cycle: Disassociation of Processive Complex and Completed Telomere End
orthologousEvent	[Reaction:R-GGA-174448] Formation of Processive Complex on the C-strand of the telomere - Gallus gallus [Reaction:R-SSC-174448] Formation of Processive Complex on the C-strand of the telomere - Sus scrofa [Reaction:R-BTA-174448] Formation of Processive Complex on the C-strand of the telomere - Bos taurus [Reaction:R-CFA-174448] Formation of Processive Complex on the C-strand of the telomere - Canis familiaris [Reaction:R-RNO-174448] Formation of Processive Complex on the C-strand of the telomere - Rattus norvegicus [Reaction:R-MMU-174448] Formation of Processive Complex on the C-strand of the telomere - Mus musculus
output	[Complex:R-HSA-174453] Processive complex loaded on telomere [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174447] RFC dissociates after sliding clamp formation on the C-strand of the telomere - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174448
summation	[Summation:9668892] The loading of proliferating cell nuclear antigen (PCNA) lea...
updateTrackers	[UpdateTracker:9776991] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v73:[modifyText] [UpdateTracker:9780992] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v61:[addLiteratureReference, modifyText] [UpdateTracker:9783009] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v57:[modifyText] [UpdateTracker:9777198] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v72:[add_removeLiteratureReference, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9776991] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v73:[modifyText] [UpdateTracker:9780992] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v61:[addLiteratureReference, modifyText] [UpdateTracker:9783009] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v57:[modifyText] [UpdateTracker:9777198] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v72:[add_removeLiteratureReference, add_removeSummation]
(hasEvent)	[Pathway:R-HSA-174411] Polymerase switching on the C-strand of the telomere
(precedingEvent)	[Reaction:R-HSA-174444] Formation of C-strand Okazaki fragments

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