Reactome | LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)

Schema > Reaction > Entries

LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) Show undefined attributes

authored	[InstanceEdit:197112] D'Eustachio, P, 2007-04-30 14:17:00
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:171140] D'Eustachio, P, 2006-01-28 18:01:52
dbId	171141
deleted	[Deleted:8964198] Deletion of instance: 171118
displayName	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)
edited	[InstanceEdit:174830] D'Eustachio, P, 2006-02-20 18:35:05
eventOf	[Pathway:R-HSA-8964038] LDL clearance - Homo sapiens
followingEvent	[Reaction:R-HSA-171059] LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] - Homo sapiens
input	[Complex:R-HSA-171100] LDL:LDLR complex [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:171046] Coated pits, coated vesicles, and receptor-mediated endocytosis [LiteratureReference:171130] ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2 [LiteratureReference:171084] Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1 [LiteratureReference:171116] The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits [LiteratureReference:171152] The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) Internalization of LDL:LDLR complex (LDLRAP1-independent)
orthologousEvent	[Reaction:R-SSC-171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - Sus scrofa [Reaction:R-BTA-171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - Bos taurus [Reaction:R-CFA-171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - Canis familiaris [Reaction:R-RNO-171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - Rattus norvegicus [Reaction:R-MMU-171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - Mus musculus
output	[Complex:R-HSA-171108] LDL:LDLR complex [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-HSA-171122] LDL + LDLR => LDL:LDLR complex - Homo sapiens
regulatedBy	[Requirement:R-HSA-171103] Requirement by 'LDLRAP1 [plasma membrane]'
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-171141
summation	[Summation:171079] Low density lipoprotein (LDL) particles bound to their recep...
updateTrackers	[UpdateTracker:9781930] Update Tracker - [Reaction:171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - v60:[addLiteratureReference, addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9781930] Update Tracker - [Reaction:171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - v60:[addLiteratureReference, addRegulator]
(replacementInstances)	[Deleted:8964198] Deletion of instance: 171118
(hasEvent)	[Pathway:R-HSA-8964038] LDL clearance
(precedingEvent)	[Reaction:R-HSA-171059] LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]

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