Reactome | LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)

Schema > Reaction > Entries

LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10239130
displayName	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)
eventOf	[Pathway:R-CFA-8964038] LDL clearance - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-171059] LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] - Canis familiaris
inferredFrom	[Reaction:R-HSA-171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - Homo sapiens
input	[Complex:R-CFA-171100] LDL:LDLR complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) Internalization of LDL:LDLR complex (LDLRAP1-independent)
output	[Complex:R-CFA-171108] LDL:LDLR complex [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-CFA-171122] LDL + LDLR => LDL:LDLR complex - Canis familiaris
regulatedBy	[Requirement:10239131] Requirement by 'LDLRAP1 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-171141
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8964038] LDL clearance
(precedingEvent)	[Reaction:R-CFA-171059] LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
(inferredTo)	[Reaction:R-HSA-171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)

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