Reactome | TGFBR2 phosphorylates TGFBR1

Schema > Reaction > Entries

TGFBR2 phosphorylates TGFBR1 Show undefined attributes

authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
catalystActivity	[CatalystActivity:170856] transforming growth factor beta receptor activity, type II of TGFB1:TGFBR2:TGFBR1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
dbId	170843
diseaseReaction	[FailedReaction:R-HSA-3645780] TGFBR2 KD mutants do not phosphorylate TGFBR1 - Homo sapiens
displayName	TGFBR2 phosphorylates TGFBR1
edited	[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
eventOf	[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs - Homo sapiens
followingEvent	[Reaction:R-HSA-2127562] STRAP binds phosphorylated TGF-beta receptor complex - Homo sapiens [Reaction:R-HSA-170835] An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-170840] TGFB1:TGFBR2:TGFBR1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:175963] Mechanism of activation of the TGF-beta receptor [LiteratureReference:175965] Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses [LiteratureReference:4127454] The type I TGF-beta receptor is covalently modified and regulated by sumoylation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	TGFBR2 phosphorylates TGFBR1 Type II receptor phosphorylates type I receptor
orthologousEvent	[Reaction:R-DME-170843] TGFBR2 phosphorylates TGFBR1 - Drosophila melanogaster [Reaction:R-XTR-170843] TGFBR2 phosphorylates TGFBR1 - Xenopus tropicalis [Reaction:R-DRE-170843] TGFBR2 phosphorylates TGFBR1 - Danio rerio [Reaction:R-SSC-170843] TGFBR2 phosphorylates TGFBR1 - Sus scrofa [Reaction:R-BTA-170843] TGFBR2 phosphorylates TGFBR1 - Bos taurus [Reaction:R-CFA-170843] TGFBR2 phosphorylates TGFBR1 - Canis familiaris [Reaction:R-RNO-170843] TGFBR2 phosphorylates TGFBR1 - Rattus norvegicus [Reaction:R-MMU-170843] TGFBR2 phosphorylates TGFBR1 - Mus musculus
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-170841] TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-170846] TGFBR2 recruits TGFBR1 - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12 [InstanceEdit:2250308] Huang, Tao, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-170843
summation	[Summation:176016] Formation of the hetero-tetrameric TGF-beta-1 receptor compl...
updateTrackers	[UpdateTracker:9789304] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v38:[modifyText] [UpdateTracker:9787015] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v46:[addLiteratureReference] [UpdateTracker:9788519] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v41:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789304] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v38:[modifyText] [UpdateTracker:9787015] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v46:[addLiteratureReference] [UpdateTracker:9788519] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v41:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-3645780] TGFBR2 KD mutants do not phosphorylate TGFBR1
(precedingEvent)	[Reaction:R-HSA-2127562] STRAP binds phosphorylated TGF-beta receptor complex [Reaction:R-HSA-170835] An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
(hasEvent)	[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs

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