TGFBR2 phosphorylates TGFBR1

Stable Identifier
R-HSA-170843
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Type II receptor phosphorylates type I receptor
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Formation of the hetero-tetrameric TGF-beta-1 receptor complex induces receptor rotation, so that TGFBR2 and TGFBR1 cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain (GS domain) of the type I receptor (Wrana et al. 1994, Souchelnytskyi et al. 1996).

In addition to phosphorylation, TGFBR1 may also be sumoylated in response to TGF-beta-1 stimulation. Sumoylation enhances TGFBR1 function by facilitating recruitment and phosphorylation of SMAD3 (Kang et al. 2008).

Literature References
PubMed ID Title Journal Year
8047140 Mechanism of activation of the TGF-beta receptor

Wrana, JL, Attisano, L, Wieser, R, Ventura, F, Massague, J

Nature 1994
8947046 Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses

Souchelnytskyi, S, ten Dijke, P, Miyazono, K, Heldin, CH

EMBO J 1996
18469808 The type I TGF-beta receptor is covalently modified and regulated by sumoylation

Kang, JS, Saunier, EF, Akhurst, RJ, Derynck, R

Nat. Cell Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transforming growth factor beta receptor activity, type II of TGFB1:TGFBR2:TGFBR1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created