Reactome | TGFBR2 phosphorylates TGFBR1

TGFBR2 phosphorylates TGFBR1

Stable Identifier

R-HSA-170843

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Type II receptor phosphorylates type I receptor

ReviewStatus

5/5

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Formation of the hetero-tetrameric TGF-beta-1 receptor complex induces receptor rotation, so that TGFBR2 and TGFBR1 cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain (GS domain) of the type I receptor (Wrana et al. 1994, Souchelnytskyi et al. 1996).

In addition to phosphorylation, TGFBR1 may also be sumoylated in response to TGF-beta-1 stimulation. Sumoylation enhances TGFBR1 function by facilitating recruitment and phosphorylation of SMAD3 (Kang et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
8947046	Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses Miyazono, K, Souchelnytskyi, S, ten Dijke, P, Heldin, CH	EMBO J	1996
8047140	Mechanism of activation of the TGF-beta receptor Massague, J, Wrana, JL, Wieser, R, Attisano, L, Ventura, F	Nature	1994
18469808	The type I TGF-beta receptor is covalently modified and regulated by sumoylation Derynck, R, Kang, JS, Akhurst, RJ, Saunier, EF	Nat. Cell Biol.	2008