Reactome | Inhibition of IFN-beta

Schema > Pathway > Entries

authored	[InstanceEdit:5146782] Gillespie, ME, 2013-11-18
created	[InstanceEdit:168887] 2007-04-16 22:35:07
crossReference	[DatabaseIdentifier:12020763] Mondo:0005812
dbId	168888
disease	[Disease:1660558] influenza
displayName	Inhibition of IFN-beta
eventOf	[Pathway:R-HSA-168305] Inhibition of Interferon Synthesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160451] negative regulation of defense response to virus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-168891] Binding of NS1 to dsRNA - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-09-30
literatureReference	[LiteratureReference:169067] A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
maxDepth	2
modified	[InstanceEdit:9953541] Gillespie, Marc E, 2025-06-03
name	Inhibition of IFN-beta
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:170177] Gale M, Jr, 2004-05-12 19:00:00
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-168888
summation	[Summation:169119] Since the presence of intracellular dsRNA serves as the sign...
updateTrackers	[UpdateTracker:9784511] Update Tracker - [Pathway:168888] Inhibition of IFN-beta - v54:[updateContainedRLE] [UpdateTracker:9789427] Update Tracker - [Pathway:168888] Inhibition of IFN-beta - v38:[addLiteratureReference]

(updatedInstance)	[UpdateTracker:9784511] Update Tracker - [Pathway:168888] Inhibition of IFN-beta - v54:[updateContainedRLE] [UpdateTracker:9789427] Update Tracker - [Pathway:168888] Inhibition of IFN-beta - v38:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-168305] Inhibition of Interferon Synthesis

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