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Inhibition of IFN-beta
Stable Identifier
R-HSA-168888
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Inhibition of Interferon Synthesis (Homo sapiens)
Inhibition of IFN-beta (Homo sapiens)
General
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Since the presence of intracellular dsRNA serves as the signal for virus infection and triggers host interferon (IFN) synthesis the simplest model for viral NS1 protein function is that it sequesters dsRNA and thus prevents the downstream signaling required to activate IRF-3, NF-kB and AP-1. These findings are strongly supported by mutational analyses of NS1 that indicate that the IFN antagonist properties of NS1 depend on its ability to bind dsRNA. However, a compensatory mutation (S42G), which was acquired during the passaging of the mutant RNA-binding virus, results in partial restoration of wild-type phenotype but does not restore RNA binding. This indicates that the ability of NS1 to inhibit IFN synthesis is not solely dependent on dsRNA binding and that additional mechanisms may be involved.
Literature References
PubMed ID
Title
Journal
Year
14645582
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
Garcia-Sastre, A
,
Donelan, NR
,
Basler, CF
J Virol
2003
Participants
Events
Binding of NS1 to dsRNA
(Homo sapiens)
Participates
as an event of
Inhibition of Interferon Synthesis (Homo sapiens)
Event Information
Go Biological Process
mitigation of host antiviral defense response (0019049)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME (2013-11-18)
Reviewed
Gale M, Jr (2004-05-12)
Created
© 2024
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