Reactome | Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex

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Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex Show undefined attributes

authored	[InstanceEdit:1679075] Shamovsky, V, 2011-10-19
category	dissociation
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1679075] Shamovsky, V, 2011-10-19
dbId	1678944
displayName	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex
edited	[InstanceEdit:2129343] Shamovsky, V, 2012-02-19
eventOf	[Pathway:R-HSA-1679131] Trafficking and processing of endosomal TLR - Homo sapiens
followingEvent	[Reaction:R-HSA-1678921] Full-length TLR3/7/8/9 binds to UNC93B1 - Homo sapiens
input	[Complex:R-HSA-1679076] ATP-bound Gp96 dimer:CNPY3:TLR7/8/9 [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1678975] Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex
orthologousEvent	[Reaction:R-SSC-1678944] Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex - Sus scrofa [Reaction:R-BTA-1678944] Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex - Bos taurus [Reaction:R-CFA-1678944] Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex - Canis familiaris [Reaction:R-RNO-1678944] Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex - Rattus norvegicus [Reaction:R-MMU-1678944] Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex - Mus musculus
output	2 × [SimpleEntity:R-ALL-211606] ADP [endoplasmic reticulum membrane] [Complex:R-HSA-1678941] Apo-GP96 dimer [endoplasmic reticulum lumen] 2 × [EntityWithAccessionedSequence:R-HSA-1678932] CNPY3 [endoplasmic reticulum lumen] [DefinedSet:R-HSA-1679066] folded FL-TLR7/8/9 [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1678923] TLR folding by chaperones GP96 and CNPY3 - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121211] Gillespie, ME, 2012-02-09 [InstanceEdit:2153487] Leifer, CA, Rose II, WA, 2012-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1678944
summation	[Summation:1679051] Folded TLR9 dissociates from GP96:CNPY3 complex (Liu B et a...

Referrals

(hasEvent)	[Pathway:R-HSA-1679131] Trafficking and processing of endosomal TLR
(precedingEvent)	[Reaction:R-HSA-1678921] Full-length TLR3/7/8/9 binds to UNC93B1

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