Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex

Stable Identifier
R-HSA-1678944
Type
Reaction
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
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Summation

Folded TLR9 dissociates from GP96:CNPY3 complex (Liu B et al 2010) and translocates to the endolysosome with the aid of the membrane protein UNC93b. Here we assume that TLR7 and TLR8 behave in a similar manner.

Literature References
PubMed ID Title Journal Year
20865800 Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

Liu, B, Yang, Y, Qiu, Z, Staron, M, Hong, F, Li, Y, Wu, S, Li, Y, Hao, B, Bona, R, Han, D, Li, Z

Nat Commun 2010
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Orthologous Events
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Bos taurus)
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Canis familiaris)
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Danio rerio)
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Drosophila melanogaster)
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Gallus gallus)
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Mus musculus)
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Rattus norvegicus)
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Sus scrofa)
Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Taeniopygia guttata)
Authored
Shamovsky, V  (2011-10-19)
Reviewed
Gillespie, ME  (2012-02-09)
Leifer, CA  (2012-02-28)
Rose II, WA  (2012-02-28)