Reactome | Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex

Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex

Stable Identifier

R-HSA-1678944

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

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General

SBML |

SVG | | PPTX | SBGN

Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex

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Folded TLR9 dissociates from GP96:CNPY3 complex (Liu B et al 2010) and translocates to the endolysosome with the aid of the membrane protein UNC93b. Here we assume that TLR7 and TLR8 behave in a similar manner.

Literature References

PubMed ID	Title	Journal	Year
20865800	Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone Liu, B, Yang, Y, Qiu, Z, Staron, M, Hong, F, Li, Y, Wu, S, Li, Y, Hao, B, Bona, R, Han, D, Li, Z	Nat Commun	2010