Reactome | IDUA cleaves iduronate from HS chain

Schema > Reaction > Entries

IDUA cleaves iduronate from HS chain Show undefined attributes

authored	[InstanceEdit:1678699] Jassal, B, 2011-10-19
catalystActivity	[CatalystActivity:1678683] L-iduronidase activity of IDUA [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1678699] Jassal, B, 2011-10-19
dbId	1678716
diseaseReaction	[FailedReaction:R-HSA-9036037] Defective IDUA does not hydrolyse Heparan sulfate chain(1) - Homo sapiens
displayName	IDUA cleaves iduronate from HS chain
edited	[InstanceEdit:1678699] Jassal, B, 2011-10-19
eventOf	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-1678708] SGSH hydrolyses Heparan sulfate chain(2) - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-2090033] IdoA-GlcN6S-IdoA2S-GlcN3S- group [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1678628] Human alpha-L-iduronidase: cDNA isolation and expression [LiteratureReference:1678646] Mucopolysaccharidosis type I: characterization of novel mutations affecting alpha-L-iduronidase activity
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	IDUA cleaves iduronate from HS chain IDUA hydrolyses Heparan sulfate chain(1)
orthologousEvent	[Reaction:R-BTA-1678716] IDUA cleaves iduronate from HS chain - Bos taurus [Reaction:R-DDI-1678716] IDUA cleaves iduronate from HS chain - Dictyostelium discoideum [Reaction:R-DME-1678716] IDUA cleaves iduronate from HS chain - Drosophila melanogaster [Reaction:R-GGA-1678716] IDUA cleaves iduronate from HS chain - Gallus gallus [Reaction:R-XTR-1678716] IDUA cleaves iduronate from HS chain - Xenopus tropicalis [Reaction:R-DRE-1678716] IDUA cleaves iduronate from HS chain - Danio rerio [Reaction:R-SSC-1678716] IDUA cleaves iduronate from HS chain - Sus scrofa [Reaction:R-CFA-1678716] IDUA cleaves iduronate from HS chain - Canis familiaris [Reaction:R-RNO-1678716] IDUA cleaves iduronate from HS chain - Rattus norvegicus [Reaction:R-MMU-1678716] IDUA cleaves iduronate from HS chain - Mus musculus
output	[SimpleEntity:R-ALL-1678617] aldehydo-L-iduronic acid [lysosomal lumen] [SimpleEntity:R-ALL-2090072] GlcNS6S-IdoAS2-GlcNS3S- group [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1667005] Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1678716
summation	[Summation:1678630] The lysosomal enzyme alpha-L-iduronidase (IDUA) cleaves the ...
updateTrackers	[UpdateTracker:9953742] Update Tracker - [Reaction:1678716] IDUA cleaves iduronate from HS chain - v93:[modifyText] [UpdateTracker:9788466] Update Tracker - [Reaction:1678716] IDUA hydrolyses Heparan sulfate chain(1) - v42:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9953742] Update Tracker - [Reaction:1678716] IDUA cleaves iduronate from HS chain - v93:[modifyText] [UpdateTracker:9788466] Update Tracker - [Reaction:1678716] IDUA hydrolyses Heparan sulfate chain(1) - v42:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-9036037] Defective IDUA does not hydrolyse Heparan sulfate chain(1)
(hasEvent)	[Pathway:R-HSA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-HSA-1678708] SGSH hydrolyses Heparan sulfate chain(2)