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PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane
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authored
[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity
[CatalystActivity:1806254] phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR2,MTMR4,MTMR7 [cytosol]
category
transition
compartment
[Compartment:172574] late endosome membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1676083] Williams, MG, 2011-10-17
crossReference
[DatabaseIdentifier:11880053] Rhea:39019
dbId
1676065
displayName
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane
edited
[InstanceEdit:1482514] Williams, MG, 2011-08-12
[InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
eventOf
[Pathway:R-HSA-1660517] Synthesis of PIPs at the late endosome membrane - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-1806289] PI(3,5)P2 [late endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1675845] Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions
[LiteratureReference:1675811] Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction
[LiteratureReference:1675809] Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells
[LiteratureReference:1675786] Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes
[LiteratureReference:1675857] Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking
[LiteratureReference:1676117] Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane
orthologousEvent
[Reaction:R-SCE-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Saccharomyces cerevisiae
[Reaction:R-SPO-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Schizosaccharomyces pombe
[Reaction:R-DDI-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Dictyostelium discoideum
[Reaction:R-CEL-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Caenorhabditis elegans
[Reaction:R-DME-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Drosophila melanogaster
[Reaction:R-GGA-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Gallus gallus
[Reaction:R-XTR-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Xenopus tropicalis
[Reaction:R-DRE-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Danio rerio
[Reaction:R-SSC-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Sus scrofa
[Reaction:R-BTA-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Bos taurus
[Reaction:R-CFA-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Canis familiaris
[Reaction:R-RNO-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Rattus norvegicus
[Reaction:R-MMU-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Mus musculus
output
[SimpleEntity:R-ALL-29372] Pi [cytosol]
[SimpleEntity:R-ALL-1806212] PI5P [late endosome membrane]
precedingEvent
[Reaction:R-HSA-1676041] Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome - Homo sapiens
[Reaction:R-HSA-1675910] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
[InstanceEdit:8959443] Rush, Mark G, 2017-01-10
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1676065
summation
[Summation:1676015] At the late endosome membrane, myotubularin (MTM1), myotubul...
Referrals
(hasEvent)
[Pathway:R-HSA-1660517] Synthesis of PIPs at the late endosome membrane
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