Reactome | PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane

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PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806254] phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR2,MTMR4,MTMR7 [cytosol]
category	transition
compartment	[Compartment:172574] late endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
crossReference	[DatabaseIdentifier:11880053] Rhea:39019
dbId	1676065
displayName	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12 [InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
eventOf	[Pathway:R-HSA-1660517] Synthesis of PIPs at the late endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806289] PI(3,5)P2 [late endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1675845] Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions [LiteratureReference:1675811] Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction [LiteratureReference:1675809] Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells [LiteratureReference:1675786] Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes [LiteratureReference:1675857] Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking [LiteratureReference:1676117] Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane
orthologousEvent	[Reaction:R-SCE-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Schizosaccharomyces pombe [Reaction:R-DDI-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Dictyostelium discoideum [Reaction:R-CEL-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Caenorhabditis elegans [Reaction:R-DME-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Drosophila melanogaster [Reaction:R-GGA-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Gallus gallus [Reaction:R-XTR-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Xenopus tropicalis [Reaction:R-DRE-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Danio rerio [Reaction:R-SSC-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Sus scrofa [Reaction:R-BTA-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Bos taurus [Reaction:R-CFA-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Canis familiaris [Reaction:R-RNO-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Rattus norvegicus [Reaction:R-MMU-1676065] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806212] PI5P [late endosome membrane]
precedingEvent	[Reaction:R-HSA-1676041] Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome - Homo sapiens [Reaction:R-HSA-1675910] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14 [InstanceEdit:8959443] Rush, Mark G, 2017-01-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676065
summation	[Summation:1676015] At the late endosome membrane, myotubularin (MTM1), myotubul...

Referrals

(hasEvent)

[Pathway:R-HSA-1660517] Synthesis of PIPs at the late endosome membrane

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