Reactome | PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane

Schema > Reaction > Entries

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806283] 1-phosphatidylinositol-3-phosphate 5-kinase activity of PIKFYVE:VAC14:FIG4 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
crossReference	[DatabaseIdentifier:12667425] RHEA:13609
dbId	1675921
displayName	PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660514] Synthesis of PIPs at the Golgi membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1676005] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane - Homo sapiens
inferredFrom	[Reaction:R-NUL-1675982] PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the Golgi membrane - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-1806159] PI3P [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1675955] PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin [LiteratureReference:1675907] Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases [LiteratureReference:1675790] Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex [LiteratureReference:1460276] ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality [LiteratureReference:1676068] Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1806290] PI(3,5)P2 [Golgi membrane]
precedingEvent	[Reaction:R-HSA-1676005] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane - Homo sapiens [Reaction:R-HSA-1675961] PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1675921
summation	[Summation:1675926] At the Golgi membrane, the PAS complex, consisting of FYVE f...

Referrals

(hasEvent)	[Pathway:R-HSA-1660514] Synthesis of PIPs at the Golgi membrane
(precedingEvent)	[Reaction:R-HSA-1676005] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
(inferredTo)	[Reaction:R-NUL-1675982] PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the Golgi membrane