Reactome | Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP

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Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP Show undefined attributes

authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:167126] Matthews, L, 2005-10-11 08:30:05
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	167130
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP
edited	[InstanceEdit:165066] Matthews, L, 2005-07-26 23:29:22
eventOf	[Pathway:R-HSA-167161] HIV Transcription Initiation - Homo sapiens
followingEvent	[Reaction:R-HSA-167134] Newly formed phosphodiester bond stabilized and PPi released - Homo sapiens
inferredFrom	[Reaction:R-HSA-75866] Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP - Homo sapiens
input	[Complex:R-HSA-167129] HIV-1 initiation complex [nucleoplasm]
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:110387] Three transitions in the RNA polymerase II transcription complex during initiation.
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP
output	[Complex:R-HSA-167106] HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm]
precedingEvent	[Reaction:R-HSA-167118] NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-167130
summation	[Summation:179004] At the beginning of this reaction, 1 molecule of 'HIV-1 init...
updateTrackers	[UpdateTracker:9784275] Update Tracker - [Reaction:167130] Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP - v54:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9784275] Update Tracker - [Reaction:167130] Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP - v54:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-167161] HIV Transcription Initiation
(precedingEvent)	[Reaction:R-HSA-167134] Newly formed phosphodiester bond stabilized and PPi released
(inferredTo)	[Reaction:R-HSA-75866] Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP

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