Reactome | FGFR2 N549K [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

FGFR2 N549K [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2033329] FGFR2 N549K mutant dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:1637912] Rothfels, K, 2011-10-05
crossReference	[DatabaseIdentifier:2033264] COSMIC:COSV60639738 [DatabaseIdentifier:2033262] COSMIC:COSV60638757
dbId	1637910
disease	[Disease:1614674] female reproductive endometrioid cancer [Disease:1500689] cancer
displayName	FGFR2 N549K [plasma membrane]
endCoordinate	821
hasModifiedResidue	[ReplacedResidue:1637911] L-asparagine 549 replaced with L-lysine
inDisease	true
literatureReference	[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1637872] Activation of FGF receptors by mutations in the transmembrane domain [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
memberOf	[CandidateSet:R-HSA-2033351] FGFR2 mutants with enhanced kinase activity [plasma membrane] - Homo sapiens
modified	[InstanceEdit:5649534] Rothfels, Karen, 2014-11-20
name	FGFR2 N549K
referenceEntity	[ReferenceGeneProduct:403305] UniProt:P21802 FGFR2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1637910
startCoordinate	22

Referrals

(hasComponent)	[Complex:R-HSA-2033329] FGFR2 N549K mutant dimer [plasma membrane]
(hasMember)	[CandidateSet:R-HSA-2033351] FGFR2 mutants with enhanced kinase activity [plasma membrane]