Reactome | FGFR2 K660N [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

FGFR2 K660N [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2033331] FGFR2 K660N mutant dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-2033331] FGFR2 K660N mutant dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:1637906] Rothfels, K, 2011-10-05
crossReference	[DatabaseIdentifier:12021291] Mondo:0007405 [DatabaseIdentifier:2033259] COSMIC:COSV60655029
dbId	1637905
disease	[Disease:1614674] female reproductive endometrioid cancer [Disease:1625203] Crouzon syndrome [Disease:2032940] bone development disease [Disease:1500689] cancer
displayName	FGFR2 K660N [plasma membrane]
endCoordinate	821
hasModifiedResidue	[ReplacedResidue:1637907] L-lysine 660 replaced with L-asparagine
inDisease	true
literatureReference	[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:2033246] Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis [LiteratureReference:2033243] A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases
maxDepth	1
memberOf	[CandidateSet:R-HSA-2033351] FGFR2 mutants with enhanced kinase activity [plasma membrane] - Homo sapiens
modified	[InstanceEdit:5649532] Rothfels, Karen, 2014-11-20
name	FGFR2 K660N
referenceEntity	[ReferenceGeneProduct:uniprot:P21802] UniProt:P21802 FGFR2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1637905
startCoordinate	22
updateTrackers	[UpdateTracker:9889931] Update Tracker - [EntityWithAccessionedSequence:1637905] FGFR2 K660N [plasma membrane] - v52:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9889931] Update Tracker - [EntityWithAccessionedSequence:1637905] FGFR2 K660N [plasma membrane] - v52:[modifyName]
(hasComponent)	[Complex:R-HSA-2033331] FGFR2 K660N mutant dimer [plasma membrane]
(hasMember)	[CandidateSet:R-HSA-2033351] FGFR2 mutants with enhanced kinase activity [plasma membrane]

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