Reactome | phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

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phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP Show undefined attributes

authored	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
catalystActivity	[CatalystActivity:162711] UDP-glycosyltransferase activity of GPI-GnT [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
dbId	162730
displayName	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-162710] Synthesis of glycosylphosphatidylinositol (GPI) - Homo sapiens
followingEvent	[Reaction:R-HSA-162857] N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate - Homo sapiens
input	[SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-162756] UDP-GlcNAc [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9012977] The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component [LiteratureReference:162842] PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum [LiteratureReference:162794] The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 [LiteratureReference:162736] Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP
orthologousEvent	[Reaction:R-SPO-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Schizosaccharomyces pombe [Reaction:R-DDI-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Dictyostelium discoideum [Reaction:R-DME-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Drosophila melanogaster [Reaction:R-GGA-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Gallus gallus [Reaction:R-XTR-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Xenopus tropicalis [Reaction:R-SSC-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Sus scrofa [Reaction:R-BTA-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Bos taurus [Reaction:R-RNO-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Rattus norvegicus [Reaction:R-MMU-162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-8855657] N-acetylglucosaminyl-PI [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-110096] UDP [cytosol]
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-162730
summation	[Summation:162757] The first step of GPI synthesis is the transfer of N-acetylg...
updateTrackers	[UpdateTracker:9780511] Update Tracker - [Reaction:162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - v62:[addLiteratureReference, modifyText] [UpdateTracker:9783620] Update Tracker - [Reaction:162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - v56:[add_removeOutput] [UpdateTracker:9787083] Update Tracker - [Reaction:162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - v46:[add_removeInput] [UpdateTracker:9774928] Update Tracker - [Reaction:162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - v80:[addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9780511] Update Tracker - [Reaction:162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - v62:[addLiteratureReference, modifyText] [UpdateTracker:9783620] Update Tracker - [Reaction:162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - v56:[add_removeOutput] [UpdateTracker:9787083] Update Tracker - [Reaction:162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - v46:[add_removeInput] [UpdateTracker:9774928] Update Tracker - [Reaction:162730] phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP - v80:[addOutput]
(hasEvent)	[Pathway:R-HSA-162710] Synthesis of glycosylphosphatidylinositol (GPI)
(precedingEvent)	[Reaction:R-HSA-162857] N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate

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