Reactome | phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

Stable Identifier

R-HSA-162730

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

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The first step of GPI synthesis is the transfer of N-acetylglucosamine from cytosolic UDP-N-acetylglucosamine to phosphatidyl inositol (PI) in the endoplasmic reticulum membrane. The reaction is catalyzed by a multimeric enzyme, also localized to the endoplasmic reticulum membrane, seven components of which have been identified to date by mutagenesis studies in cultured cells and by co-precipitation and reconstitution studies in vitro (Murakami et al. 2005; Watanabe et al. 1996, 1998, 2000).

Literature References

PubMed ID	Title	Journal	Year
9463366	The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 Watanabe, R, Inoue, N, Westfall, B, Taron, CH, Orlean, P, Takeda, J, Kinoshita, T	EMBO J	1998
8900170	PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum Watanabe, R, Kinoshita, T, Masaki, R, Yamamoto, A, Takeda, J, Inoue, N	J Biol Chem	1996
16162815	The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component Murakami, Y, Siripanyaphinyo, U, Hong, Y, Tashima, Y, Maeda, Y, Kinoshita, T	Mol. Biol. Cell	2005
10944123	Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2 Watanabe, R, Murakami, Y, Marmor, MD, Inoue, N, Maeda, Y, Hino, J, Kangawa, K, Julius, M, Kinoshita, T	EMBO J	2000