Reactome | phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

Stable Identifier

R-HSA-162730

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The first step of GPI synthesis is the transfer of N-acetylglucosamine from cytosolic UDP-N-acetylglucosamine to phosphatidyl inositol (PI) in the endoplasmic reticulum membrane. The reaction is catalyzed by a multimeric enzyme, also localized to the endoplasmic reticulum membrane, seven components of which have been identified to date by mutagenesis studies in cultured cells and by co-precipitation and reconstitution studies in vitro (Murakami et al. 2005; Watanabe et al. 1996, 1998, 2000).

Literature References

PubMed ID	Title	Journal	Year
9463366	The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 Kinoshita, T, Takeda, J, Taron, CH, Orlean, P, Westfall, B, Inoue, N, Watanabe, R	EMBO J	1998
8900170	PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum Kinoshita, T, Takeda, J, Inoue, N, Watanabe, R, Yamamoto, A, Masaki, R	J Biol Chem	1996
16162815	The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component Kinoshita, T, Murakami, Y, Tashima, Y, Maeda, Y, Siripanyaphinyo, U, Hong, Y	Mol. Biol. Cell	2005
10944123	Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2 Kinoshita, T, Murakami, Y, Kangawa, K, Hino, J, Inoue, N, Watanabe, R, Marmor, MD, Maeda, Y, Julius, M	EMBO J	2000