Reactome | glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH

Schema > Reaction > Entries

glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH Show undefined attributes

authored	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
catalystActivity	[CatalystActivity:162878] O-acyltransferase activity of PIGW [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
dbId	162683
displayName	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-162710] Synthesis of glycosylphosphatidylinositol (GPI) - Homo sapiens
followingEvent	[Reaction:R-HSA-162840] Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane - Homo sapiens [Reaction:R-HSA-162830] glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-75967] FACoA [cytosol] [SimpleEntity:R-ALL-8855661] glucosaminyl-PI [cytoplasmic side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:162841] PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH
orthologousEvent	[Reaction:R-PFA-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Plasmodium falciparum [Reaction:R-SCE-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Saccharomyces cerevisiae [Reaction:R-SPO-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Schizosaccharomyces pombe [Reaction:R-DDI-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Dictyostelium discoideum [Reaction:R-CEL-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Caenorhabditis elegans [Reaction:R-DME-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Drosophila melanogaster [Reaction:R-GGA-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Gallus gallus [Reaction:R-XTR-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Xenopus tropicalis [Reaction:R-DRE-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Danio rerio [Reaction:R-SSC-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Sus scrofa [Reaction:R-BTA-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Bos taurus [Reaction:R-CFA-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Canis familiaris [Reaction:R-RNO-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Rattus norvegicus [Reaction:R-MMU-162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - Mus musculus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-8855666] glucosaminyl-acyl-PI [cytoplasmic side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-162857] N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-162683
summation	[Summation:162701] In the fourth step of GPI synthesis, an acyl group (typicall...
updateTrackers	[UpdateTracker:9783730] Update Tracker - [Reaction:162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - v56:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9783730] Update Tracker - [Reaction:162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH - v56:[add_removeInput, add_removeOutput]
(precedingEvent)	[Reaction:R-HSA-162840] Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane [Reaction:R-HSA-162830] glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate
(hasEvent)	[Pathway:R-HSA-162710] Synthesis of glycosylphosphatidylinositol (GPI)

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