glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH

Stable Identifier
R-HSA-162683
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the fourth step of GPI synthesis, an acyl group (typically palmitate) is transferred from acyl CoA to glucosaminyl-PI. Mutagenesis and cloning studies suggest that a single protein, PIG-W, catalyzes this reaction (Murakami et al. 2003).

Literature References
PubMed ID Title Journal Year
14517336 PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor

Murakami, Y, Siripanyapinyo, U, Hong, Y, Kang, JY, Ishihara, S, Nakakuma, H, Maeda, Y, Kinoshita, T

Mol Biol Cell 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
O-acyltransferase activity of PIGW [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
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