Reactome | bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE

Schema > Reaction > Entries

bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE Show undefined attributes

authored	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
catalystActivity	[CatalystActivity:1605761] beta-N-acetylhexosaminidase activity of bHEXA,bHEXB [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
dbId	1605632
displayName	bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE
edited	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-1605736] GLA hydrolyzes PSAP(195-273):Gb3Cer:PE - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [Complex:R-HSA-9840842] PSAP(195-273):Gb4Cer:PE [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1605770] Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase [LiteratureReference:1660678] Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits [LiteratureReference:1660671] Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease [LiteratureReference:9840835] Enzyme alterations and lipid storage in three variants of Tay-Sachs disease [LiteratureReference:9840311] Ganglioside Metabolism in Health and Disease [LiteratureReference:9840312] Emerging concepts of ganglioside metabolism [LiteratureReference:9840850] Purification and characterization of beta-N-acetylhexosaminidase I from human placenta [LiteratureReference:9840817] Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs. Multiple glycolipid elevations (including lactosylceramidosis), partial enzyme deficiencies and ultrastructure of the skin in this generalized sphingolipid storage disease
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE
orthologousEvent	[Reaction:R-DDI-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Dictyostelium discoideum [Reaction:R-CEL-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Caenorhabditis elegans [Reaction:R-GGA-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Gallus gallus [Reaction:R-SSC-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Sus scrofa [Reaction:R-BTA-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Bos taurus [Reaction:R-CFA-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Canis familiaris [Reaction:R-RNO-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Rattus norvegicus [Reaction:R-MMU-1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - Mus musculus
output	[SimpleEntity:R-ALL-1605658] GalNAc [lysosomal lumen] [Complex:R-HSA-9840848] PSAP(195-273):Gb3Cer:PE [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-9840470] PSAP(195-273) dimer:PE binds and mobilizes ligands - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1605632
summation	[Summation:1660668] The globotetraosylceramide Gb4Cer (Gb4) is cleaved by both b...
updateTrackers	[UpdateTracker:9853230] Update Tracker - [Reaction:1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - v87:[modifyText] [UpdateTracker:9842267] Update Tracker - [Reaction:1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - v86:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853230] Update Tracker - [Reaction:1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - v87:[modifyText] [UpdateTracker:9842267] Update Tracker - [Reaction:1605632] bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE - v86:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-HSA-1605736] GLA hydrolyzes PSAP(195-273):Gb3Cer:PE

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