Reactome | GBA1:SAPC hydrolyzes GlcCer

Schema > Reaction > Entries

GBA1:SAPC hydrolyzes GlcCer Show undefined attributes

authored	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
catalystActivity	[CatalystActivity:1605702] glucosylceramidase activity of GBA1:SAPC [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:161320] lysosomal lumen
created	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
dbId	1605591
displayName	GBA1:SAPC hydrolyzes GlcCer
edited	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-1606602] ASAH1 hydrolyzes ceramide - Homo sapiens
input	[SimpleEntity:R-ALL-1605592] GlcCer [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1605709] Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site [LiteratureReference:1605650] Further studies on the reconstitution of glucosylceramidase activity by Sap C and anionic phospholipids [LiteratureReference:1605752] Glucocerebrosidase (Gaucher disease) [LiteratureReference:9841144] Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal ?-glucocerebrosidase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GBA1:SAPC hydrolyzes GlcCer
orthologousEvent	[Reaction:R-CEL-1605591] GBA1:SAPC hydrolyzes GlcCer - Caenorhabditis elegans [Reaction:R-DME-1605591] GBA1:SAPC hydrolyzes GlcCer - Drosophila melanogaster [Reaction:R-GGA-1605591] GBA1:SAPC hydrolyzes GlcCer - Gallus gallus [Reaction:R-DRE-1605591] GBA1:SAPC hydrolyzes GlcCer - Danio rerio [Reaction:R-SSC-1605591] GBA1:SAPC hydrolyzes GlcCer - Sus scrofa [Reaction:R-BTA-1605591] GBA1:SAPC hydrolyzes GlcCer - Bos taurus [Reaction:R-CFA-1605591] GBA1:SAPC hydrolyzes GlcCer - Canis familiaris [Reaction:R-RNO-1605591] GBA1:SAPC hydrolyzes GlcCer - Rattus norvegicus [Reaction:R-MMU-1605591] GBA1:SAPC hydrolyzes GlcCer - Mus musculus
output	[SimpleEntity:R-ALL-1605673] CERA [lysosomal lumen] [SimpleEntity:R-ALL-1605745] Glc [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1606312] GLB1 hydrolyzes SapB/C:LacCer - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1605591
summation	[Summation:1605596] Human lysosomal glucosylceramidase (GBA1) hydrolyzes the glu...
updateTrackers	[UpdateTracker:9842364] Update Tracker - [Reaction:1605591] GBA1:SAPC hydrolyzes GlcCer - v86:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9842364] Update Tracker - [Reaction:1605591] GBA1:SAPC hydrolyzes GlcCer - v86:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-1606602] ASAH1 hydrolyzes ceramide
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism