Reactome | GBA1:SAPC hydrolyzes GlcCer

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GBA1:SAPC hydrolyzes GlcCer Show undefined attributes

catalystActivity	[CatalystActivity:10773271] glucosylceramidase activity of GBA1:SAPC [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:161320] lysosomal lumen
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10773273
displayName	GBA1:SAPC hydrolyzes GlcCer
eventOf	[Pathway:R-GGA-9840310] Glycosphingolipid catabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1606602] ASAH1 hydrolyzes ceramide - Gallus gallus
inferredFrom	[Reaction:R-HSA-1605591] GBA1:SAPC hydrolyzes GlcCer - Homo sapiens
input	[SimpleEntity:R-ALL-1605592] GlcCer [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	GBA1:SAPC hydrolyzes GlcCer
output	[SimpleEntity:R-ALL-1605673] CERA [lysosomal lumen] [SimpleEntity:R-ALL-1605745] Glc [lysosomal lumen]
precedingEvent	[Reaction:R-GGA-1606312] GLB1 hydrolyzes SapB/C:LacCer - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1605591
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-GGA-1606602] ASAH1 hydrolyzes ceramide
(inferredTo)	[Reaction:R-HSA-1605591] GBA1:SAPC hydrolyzes GlcCer

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