Reactome | Initial activation of proMMP13 by MMP3

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Initial activation of proMMP13 by MMP3 Show undefined attributes

authored	[InstanceEdit:1592294] Jupe, S, 2011-09-09
catalystActivity	[CatalystActivity:1604695] serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1604747] Jupe, S, 2011-09-19
dbId	1604752
displayName	Initial activation of proMMP13 by MMP3
edited	[InstanceEdit:2129374] Jupe, S, 2012-02-21
eventOf	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens
followingEvent	[Reaction:R-HSA-1604732] Autocatalytic activation of proMMP13 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1604702] MMP13(20-471) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1458404] Biochemical characterization of human collagenase-3
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Initial activation of proMMP13 by MMP3
orthologousEvent	[Reaction:R-DME-1604752] Initial activation of proMMP13 by MMP3 - Drosophila melanogaster [Reaction:R-CEL-1604752] Initial activation of proMMP13 by MMP3 - Caenorhabditis elegans [Reaction:R-GGA-1604752] Initial activation of proMMP13 by MMP3 - Gallus gallus [Reaction:R-XTR-1604752] Initial activation of proMMP13 by MMP3 - Xenopus tropicalis [Reaction:R-SSC-1604752] Initial activation of proMMP13 by MMP3 - Sus scrofa [Reaction:R-BTA-1604752] Initial activation of proMMP13 by MMP3 - Bos taurus [Reaction:R-CFA-1604752] Initial activation of proMMP13 by MMP3 - Canis familiaris [Reaction:R-RNO-1604752] Initial activation of proMMP13 by MMP3 - Rattus norvegicus [Reaction:R-MMU-1604752] Initial activation of proMMP13 by MMP3 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-1604703] MMP13(20-76) [extracellular region] [EntityWithAccessionedSequence:R-HSA-1604755] MMP13(77-471) [extracellular region]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2157481] Butler, GS, 2012-02-28 [InstanceEdit:2157511] Overall, CM, 2012-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1604752
summation	[Summation:1604744] MMP3 initially cleaves proMMP13 at Gly76-Leu77 followed by a...

Referrals

(hasEvent)	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases
(precedingEvent)	[Reaction:R-HSA-1604732] Autocatalytic activation of proMMP13