Initial activation of proMMP13 by MMP3

Stable Identifier
R-HSA-1604752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MMP3 initially cleaves proMMP13 at Gly76-Leu77 followed by autoprocessing at Glu103-Tyr104 (Knauper et al. 1996).

Literature References
PubMed ID Title Journal Year
8576151 Biochemical characterization of human collagenase-3

Smith, B, López-Otin, C, Knight, G, Knäuper, V, Murphy, G

J Biol Chem 1996
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]

Orthologous Events
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