Initial activation of proMMP13 by MMP3

Stable Identifier
R-HSA-1604752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Initial activation of proMMP13 by MMP3
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MMP3 initially cleaves proMMP13 at Gly76-Leu77 followed by autoprocessing at Glu103-Tyr104 (Knauper et al. 1996).
Literature References
PubMed ID Title Journal Year
8576151 Biochemical characterization of human collagenase-3

Smith, B, López-Otin, C, Knight, G, Knäuper, V, Murphy, G

J Biol Chem 1996
Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]

Physical Entity
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Initial activation of proMMP13 by MMP3 (Bos taurus)
Initial activation of proMMP13 by MMP3 (Caenorhabditis elegans)
Initial activation of proMMP13 by MMP3 (Canis familiaris)
Initial activation of proMMP13 by MMP3 (Drosophila melanogaster)
Initial activation of proMMP13 by MMP3 (Gallus gallus)
Initial activation of proMMP13 by MMP3 (Mus musculus)
Initial activation of proMMP13 by MMP3 (Rattus norvegicus)
Initial activation of proMMP13 by MMP3 (Sus scrofa)
Initial activation of proMMP13 by MMP3 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-19)
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