Reactome | Activation of MT-MMPs by FURIN

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Activation of MT-MMPs by FURIN Show undefined attributes

authored	[InstanceEdit:1592294] Jupe, S, 2011-09-09
catalystActivity	[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:1602467] Jupe, S, 2011-09-14
dbId	1602466
displayName	Activation of MT-MMPs by FURIN
edited	[InstanceEdit:2129374] Jupe, S, 2012-02-21
eventOf	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens
followingEvent	[Reaction:R-HSA-1592349] MMP14 (MT1-MMP) binds TIMP2 - Homo sapiens
input	[CandidateSet:R-HSA-1604700] proMT-MMPs [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1602459] Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity [LiteratureReference:1602482] Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2 [LiteratureReference:1604750] Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activation of MT-MMPs by FURIN
orthologousEvent	[Reaction:R-DME-1602466] Activation of MT-MMPs by FURIN - Drosophila melanogaster [Reaction:R-CEL-1602466] Activation of MT-MMPs by FURIN - Caenorhabditis elegans [Reaction:R-GGA-1602466] Activation of MT-MMPs by FURIN - Gallus gallus [Reaction:R-XTR-1602466] Activation of MT-MMPs by FURIN - Xenopus tropicalis [Reaction:R-DRE-1602466] Activation of MT-MMPs by FURIN - Danio rerio [Reaction:R-SSC-1602466] Activation of MT-MMPs by FURIN - Sus scrofa [Reaction:R-BTA-1602466] Activation of MT-MMPs by FURIN - Bos taurus [Reaction:R-CFA-1602466] Activation of MT-MMPs by FURIN - Canis familiaris [Reaction:R-RNO-1602466] Activation of MT-MMPs by FURIN - Rattus norvegicus [Reaction:R-MMU-1602466] Activation of MT-MMPs by FURIN - Mus musculus
output	[CandidateSet:R-HSA-1604727] MT-MMPs [Golgi lumen]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2157481] Butler, GS, 2012-02-28 [InstanceEdit:2157511] Overall, CM, 2012-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1602466
summation	[Summation:1602487] The membrane-type MMPs (MT-MMPs) MMP14 (MT1-MMP) (Pei et al....
updateTrackers	[UpdateTracker:9788150] Update Tracker - [Reaction:1602466] Activation of MT-MMPs by FURIN - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788150] Update Tracker - [Reaction:1602466] Activation of MT-MMPs by FURIN - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases
(precedingEvent)	[Reaction:R-HSA-1592349] MMP14 (MT1-MMP) binds TIMP2