Reactome | Activation of MT-MMPs by FURIN

Schema > Reaction > Entries

Activation of MT-MMPs by FURIN Show undefined attributes

catalystActivity	[CatalystActivity:10236675] serine-type endopeptidase activity of FURIN [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10269835
displayName	Activation of MT-MMPs by FURIN
eventOf	[Pathway:R-CFA-1592389] Activation of Matrix Metalloproteinases - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1592349] MMP14 (MT1-MMP) binds TIMP2 - Canis familiaris
inferredFrom	[Reaction:R-HSA-1602466] Activation of MT-MMPs by FURIN - Homo sapiens
input	[CandidateSet:R-CFA-1604700] proMT-MMPs [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of MT-MMPs by FURIN
output	[CandidateSet:R-CFA-1604727] MT-MMPs [Golgi lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1602466
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1592389] Activation of Matrix Metalloproteinases
(precedingEvent)	[Reaction:R-CFA-1592349] MMP14 (MT1-MMP) binds TIMP2
(inferredTo)	[Reaction:R-HSA-1602466] Activation of MT-MMPs by FURIN

Cite Us!