Reactome | proMMP9 binds TIMP1

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proMMP9 binds TIMP1 Show undefined attributes

authored	[InstanceEdit:1592294] Jupe, S, 2011-09-09
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1602467] Jupe, S, 2011-09-14
dbId	1602454
displayName	proMMP9 binds TIMP1
edited	[InstanceEdit:2129374] Jupe, S, 2012-02-21
eventOf	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1604376] MMP9(20-707) [extracellular region] [EntityWithAccessionedSequence:R-HSA-349743] TIMP1 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1602465] SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	proMMP9 binds TIMP1
orthologousEvent	[Reaction:R-CEL-1602454] proMMP9 binds TIMP1 - Caenorhabditis elegans [Reaction:R-XTR-1602454] proMMP9 binds TIMP1 - Xenopus tropicalis [Reaction:R-DRE-1602454] proMMP9 binds TIMP1 - Danio rerio [Reaction:R-SSC-1602454] proMMP9 binds TIMP1 - Sus scrofa [Reaction:R-BTA-1602454] proMMP9 binds TIMP1 - Bos taurus [Reaction:R-CFA-1602454] proMMP9 binds TIMP1 - Canis familiaris [Reaction:R-RNO-1602454] proMMP9 binds TIMP1 - Rattus norvegicus [Reaction:R-MMU-1602454] proMMP9 binds TIMP1 - Mus musculus
output	[Complex:R-HSA-1604377] proMMP9:TIMP1 [extracellular region]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2157481] Butler, GS, 2012-02-28 [InstanceEdit:2157511] Overall, CM, 2012-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1602454
summation	[Summation:1602464] ProMMP9 binds Tissue Inhibitor of Metalloproteinases 1 (TIMP...

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(hasEvent)

[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases