Reactome | PA is hydrolyzed to 1-acyl LPA by PLA2[15]

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PA is hydrolyzed to 1-acyl LPA by PLA2[15] Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1602403] A2-type glycerophospholipase activity of PLA2(15) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1602444] Williams, MG, 2011-09-14
dbId	1602446
displayName	PA is hydrolyzed to 1-acyl LPA by PLA2[15]
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483166] Synthesis of PA - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-1602448] PA [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482657] Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 [LiteratureReference:1602387] Cloning and characterization of novel mouse and human secretory phospholipase A(2)s [LiteratureReference:1602414] Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region [LiteratureReference:1482791] Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid [LiteratureReference:1602428] Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s [LiteratureReference:1602407] Cloning and recombinant expression of human group IIF-secreted phospholipase A(2) [LiteratureReference:1602361] Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2 [LiteratureReference:1602369] Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2 [LiteratureReference:1602389] Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes [LiteratureReference:1602424] Cloning and recombinant expression of a structurally novel human secreted phospholipase A2 [LiteratureReference:1602410] Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII) [LiteratureReference:8864295] Identification of a soluble form phospholipase A2 receptor as a circulating endogenous inhibitor for secretory phospholipase A2
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PA is hydrolyzed to 1-acyl LPA by PLA2[15]
orthologousEvent	[Reaction:R-CEL-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Caenorhabditis elegans [Reaction:R-DME-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Drosophila melanogaster [Reaction:R-GGA-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Gallus gallus [Reaction:R-XTR-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Xenopus tropicalis [Reaction:R-DRE-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Danio rerio [Reaction:R-SSC-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Sus scrofa [Reaction:R-BTA-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Bos taurus [Reaction:R-CFA-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Canis familiaris [Reaction:R-RNO-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Rattus norvegicus [Reaction:R-MMU-1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - Mus musculus
output	[SimpleEntity:R-ALL-1602447] 1-acyl LPA [plasma membrane] [SimpleEntity:R-ALL-1602366] LCFA(-) [plasma membrane]
regulatedBy	[NegativeRegulation:R-HSA-8864272] Negative regulation by 'PLA2R1(21-?) [extracellular region]'
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1602446
summation	[Summation:1602445] At the plasma membrane, phosphatidic acid (PA) is hydrolyzed...
updateTrackers	[UpdateTracker:9783053] Update Tracker - [Reaction:1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - v57:[addLiteratureReference, addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9783053] Update Tracker - [Reaction:1602446] PA is hydrolyzed to 1-acyl LPA by PLA2[15] - v57:[addLiteratureReference, addRegulator]
(hasEvent)	[Pathway:R-HSA-1483166] Synthesis of PA

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