PA is hydrolyzed to 1-acyl LPA by PLA2[15]

Stable Identifier
Reaction [transition]
Homo sapiens
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At the plasma membrane, phosphatidic acid (PA) is hydrolyzed, removing one of its acyl groups, to 1-acyl lysophosphatidic acid (LPA) by secretory phospholipase A2 proteins (Singer et al. 2002, Ishizaki et al. 1999). These include: Group IB (PLA2G1B) (Grataroli et al. 1982); Group IIA (PLA2G2A) (Seilhamer et al. 1989); Group IID (PLA2G2D) (Ishizaki et al. 1999); Group IIE (PLA2G2E) (Suzuki et al. 2000); Group IIF (PLA2G2F) (Valentin et al. 2000); Calcium-dependent Group V (PLA2G5) (Chen et al. 1994); Group X (PLA2G10) (Cupillard et al. 1997, Pan et al. 2002); and Group XIIA (PLA2G12A) (Gelb et al. 2000, Murakami et al. 2003).

Literature References
PubMed ID Title Journal Year
12161451 Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes

Pan, YH, Yu, BZ, Singer, AG, Ghomashchi, F, Lambeau, G, Gelb, MH, Jain, MK, Bahnson, BJ

J Biol Chem 2002
11112443 Cloning and recombinant expression of human group IIF-secreted phospholipase A(2)

Valentin, E, Singer, AG, Ghomashchi, F, Lazdunski, M, Gelb, MH, Lambeau, G

Biochem Biophys Res Commun 2000
10455175 Cloning and characterization of novel mouse and human secretory phospholipase A(2)s

Ishizaki, J, Suzuki, N, Higashino, K, Yokota, Y, Ono, T, Kawamoto, K, Fujii, N, Arita, H, Hanasaki, K

J Biol Chem 1999
9188469 Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2

Cupillard, L, Koumanov, K, Matteï, MG, Lazdunski, M, Lambeau, G

J Biol Chem 1997
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH

J Biol Chem 2002
7060561 Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region

Grataroli, R, Dijkman, R, Dutilh, CE, van der Ouderaa, F, De Haas, GH, Figarella, C

Eur J Biochem 1982
10681567 Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s

Suzuki, N, Ishizaki, J, Yokota, Y, Higashino, K, Ono, T, Ikeda, M, Fujii, N, Kawamoto, K, Hanasaki, K

J Biol Chem 2000
12522102 Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)

Murakami, M, Masuda, S, Shimbara, S, Bezzine, S, Lazdunski, M, Lambeau, G, Gelb, MH, Matsukura, S, Kokubu, F, Adachi, M, Kudo, I

J Biol Chem 2003
8300559 Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2

Chen, J, Engle, SJ, Seilhamer, JJ, Tischfield, JA

J Biol Chem 1994
2925608 Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid

Seilhamer, JJ, Pruzanski, W, Vadas, P, Plant, S, Miller, JA, Kloss, J, Johnson, LK

J Biol Chem 1989
11830583 Identification of a soluble form phospholipase A2 receptor as a circulating endogenous inhibitor for secretory phospholipase A2

Higashino Ki, K, Yokota, Y, Ono, T, Kamitani, S, Arita, H, Hanasaki, K

J. Biol. Chem. 2002
11031251 Cloning and recombinant expression of a structurally novel human secreted phospholipase A2

Gelb, MH, Valentin, E, Ghomashchi, F, Lazdunski, M, Lambeau, G

J Biol Chem 2000
Catalyst Activity

phospholipase A2 activity of PLA2(15) [extracellular region]

This event is regulated
Orthologous Events
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