Reactome | Activation of proMMP8

Schema > BlackBoxEvent > Entries

Activation of proMMP8 Show undefined attributes

authored	[InstanceEdit:1592294] Jupe, S, 2011-09-09
catalystActivity	[CatalystActivity:2127618] serine-type endopeptidase activity of proMMP8 initial activators [extracellular region]
category	omitted
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1592294] Jupe, S, 2011-09-09
dbId	1592398
displayName	Activation of proMMP8
edited	[InstanceEdit:2129374] Jupe, S, 2012-02-21
eventOf	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1604708] MMP8(21-467) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1592299] Activation of neutrophil collagenase by cathepsin G [LiteratureReference:1592357] Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activation of proMMP8
orthologousEvent	[BlackBoxEvent:R-CEL-1592398] Activation of proMMP8 - Caenorhabditis elegans [BlackBoxEvent:R-GGA-1592398] Activation of proMMP8 - Gallus gallus [BlackBoxEvent:R-XTR-1592398] Activation of proMMP8 - Xenopus tropicalis [BlackBoxEvent:R-DRE-1592398] Activation of proMMP8 - Danio rerio [BlackBoxEvent:R-SSC-1592398] Activation of proMMP8 - Sus scrofa [BlackBoxEvent:R-BTA-1592398] Activation of proMMP8 - Bos taurus [BlackBoxEvent:R-CFA-1592398] Activation of proMMP8 - Canis familiaris [BlackBoxEvent:R-RNO-1592398] Activation of proMMP8 - Rattus norvegicus [BlackBoxEvent:R-MMU-1592398] Activation of proMMP8 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-1442475] MMP8 [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-5625883] PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2157481] Butler, GS, 2012-02-28 [InstanceEdit:2157511] Overall, CM, 2012-02-28
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1592398
summation	[Summation:1592341] proMMP8 is activated by tissue kallikrein, leukocyte elastas...

Referrals

(hasEvent)

[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases