Reactome | Autocatalytic activation of proMMP2

Schema > Reaction > Entries

Autocatalytic activation of proMMP2 Show undefined attributes

authored	[InstanceEdit:1592294] Jupe, S, 2011-09-09
catalystActivity	[CatalystActivity:1604352] serine-type endopeptidase activity of MMP2(67-660) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1592294] Jupe, S, 2011-09-09
dbId	1592278
displayName	Autocatalytic activation of proMMP2
edited	[InstanceEdit:2129374] Jupe, S, 2012-02-21
eventOf	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1604345] MMP2(67-660) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1602463] Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2 [LiteratureReference:1602452] Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Autocatalytic activation of proMMP2
orthologousEvent	[Reaction:R-DME-1592278] Autocatalytic activation of proMMP2 - Drosophila melanogaster [Reaction:R-CEL-1592278] Autocatalytic activation of proMMP2 - Caenorhabditis elegans [Reaction:R-GGA-1592278] Autocatalytic activation of proMMP2 - Gallus gallus [Reaction:R-XTR-1592278] Autocatalytic activation of proMMP2 - Xenopus tropicalis [Reaction:R-DRE-1592278] Autocatalytic activation of proMMP2 - Danio rerio [Reaction:R-SSC-1592278] Autocatalytic activation of proMMP2 - Sus scrofa [Reaction:R-BTA-1592278] Autocatalytic activation of proMMP2 - Bos taurus [Reaction:R-CFA-1592278] Autocatalytic activation of proMMP2 - Canis familiaris [Reaction:R-RNO-1592278] Autocatalytic activation of proMMP2 - Rattus norvegicus [Reaction:R-MMU-1592278] Autocatalytic activation of proMMP2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-381456] MMP2(110-660) [extracellular region] [EntityWithAccessionedSequence:R-HSA-1604371] MMP2(67-109) [extracellular region]
precedingEvent	[Reaction:R-HSA-1604359] Initial activation of proMMP2 by MMP1, 7 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-2225580] Negative regulation by 'COL18A1(1572-11754) [extracellular region]'
regulationReference	[RegulationReference:9641374] Negative regulation by 'COL18A1(1572-11754) [extracellular region]' Endostatin inhibits human tongue carcinoma cell invasion and intravasation and blocks the activation of matrix metalloprotease-2, -9, and -13
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2157481] Butler, GS, 2012-02-28 [InstanceEdit:2157511] Overall, CM, 2012-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1592278
summation	[Summation:1629855] Cleaving the Asn66-Leu67 bond of MMP2 activates it sufficien...
updateTrackers	[UpdateTracker:9788650] Update Tracker - [Reaction:1592278] Autocatalytic activation of proMMP2 - v41:[addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788650] Update Tracker - [Reaction:1592278] Autocatalytic activation of proMMP2 - v41:[addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-1592389] Activation of Matrix Metalloproteinases