Autocatalytic activation of proMMP2

Stable Identifier
R-HSA-1592278
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cleaving the Asn66-Leu67 bond of MMP2 activates it sufficiently to allow autocleavage of the Asn109-Tyr110 bond (Okada et al. 1990, Strongin et al. 1993, Crabbe et al. 1994a, Atkinson et al. 1995, Sang et al. 1996). This activation is inhibited by endostatin (Nyberg et al. 2003). Residue numbering here refers to the UniProt canonical sequence.

Literature References
PubMed ID Title Journal Year
8314771 Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2

Strongin, AY, Marmer, BL, Grant, GA, Goldberg, GI

J Biol Chem 1993
8530478 Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes

Atkinson, SJ, Crabbe, T, Cowell, S, Ward, RV, Butler, MJ, Sato, H, Seiki, M, Reynolds, JJ, Murphy, G

J Biol Chem 1995
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of MMP2(67-660) [extracellular region]

This event is regulated
Orthologous Events
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