Reactome | factor VIIIa [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
consumedByEvent	[Reaction:R-HSA-9670014] Factor VIIIa dissociates - Homo sapiens [Reaction:R-HSA-5607002] Activated protein C cleaves factor VIIIa - Homo sapiens [Reaction:R-HSA-5607043] factor VIIIa associates with cell membrane - Homo sapiens
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
dbId	158307
displayName	factor VIIIa [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-HSA-158271] F8(1709-2351) [extracellular region] [EntityWithAccessionedSequence:R-HSA-158290] F8(20-391) [extracellular region] [EntityWithAccessionedSequence:R-HSA-158199] F8(392-759) [extracellular region]
inDisease	false
inferredTo	[Complex:R-MMU-158307] factor VIIIa [extracellular region] - Mus musculus [Complex:R-RNO-158307] factor VIIIa [extracellular region] - Rattus norvegicus [Complex:R-BTA-158307] factor VIIIa [extracellular region] - Bos taurus
maxDepth	2
name	factor VIIIa
producedByEvent	[Reaction:R-HSA-9822522] factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) - Homo sapiens [Reaction:R-HSA-158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-158307

(normalEntity)	[EntityFunctionalStatus:9670212] loss_of_function of FVIIIa variants [extracellular region] [EntityFunctionalStatus:9670056] gain_of_function of factor VIIIa with defective A2 domain [extracellular region] [EntityFunctionalStatus:9670057] gain_of_function of factor VIIIa with defective A1 domain [extracellular region]
(input)	[Reaction:R-HSA-9670014] Factor VIIIa dissociates [Reaction:R-HSA-5607002] Activated protein C cleaves factor VIIIa [Reaction:R-HSA-5607043] factor VIIIa associates with cell membrane
(output)	[Reaction:R-HSA-9822522] factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) [Reaction:R-HSA-158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer

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