Reactome | CUL3:KLHL12:RBX1 [cytosol]

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CUL3:KLHL12:RBX1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1504210] DVL:CUL3:KLHL12:RBX1 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1504213] DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex - Homo sapiens
created	[InstanceEdit:1504208] Rothfels, K, 2011-08-23
dbId	1504195
displayName	CUL3:KLHL12:RBX1 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-975979] CUL3 [cytosol] [EntityWithAccessionedSequence:R-HSA-1504203] KLHL12 [cytosol] [EntityWithAccessionedSequence:R-HSA-180582] RBX1 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-1504195] CUL3:KLHL12:RBX1 [cytosol] - Mus musculus [Complex:R-RNO-1504195] CUL3:KLHL12:RBX1 [cytosol] - Rattus norvegicus [Complex:R-BTA-1504195] CUL3:KLHL12:RBX1 [cytosol] - Bos taurus [Complex:R-SSC-1504195] CUL3:KLHL12:RBX1 [cytosol] - Sus scrofa [Complex:R-DRE-1504195] CUL3:KLHL12:RBX1 [cytosol] - Danio rerio [Complex:R-XTR-1504195] CUL3:KLHL12:RBX1 [cytosol] - Xenopus tropicalis [Complex:R-GGA-1504195] CUL3:KLHL12:RBX1 [cytosol] - Gallus gallus [Complex:R-DME-1504195] CUL3:KLHL12:RBX1 [cytosol] - Drosophila melanogaster [Complex:R-CEL-1504195] CUL3:KLHL12:RBX1 [cytosol] - Caenorhabditis elegans [Complex:R-DDI-1504195] CUL3:KLHL12:RBX1 [cytosol] - Dictyostelium discoideum [Complex:R-PFA-1504195] CUL3:KLHL12:RBX1 [cytosol] - Plasmodium falciparum
isChimeric	false
literatureReference	[LiteratureReference:1504211] The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation
maxDepth	2
name	CUL3:KLHL12:RBX1
producedByEvent	[BlackBoxEvent:R-HSA-1504193] Ubiquitinated DVL is degraded by the proteasome - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1504195

Referrals

(input)	[Reaction:R-HSA-1504213] DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
(hasComponent)	[Complex:R-HSA-1504210] DVL:CUL3:KLHL12:RBX1 [cytosol] [Complex:R-HSA-4652690] ub-DVL:CUL3:KLHL12:RBX1 [cytosol]
(output)	[BlackBoxEvent:R-HSA-1504193] Ubiquitinated DVL is degraded by the proteasome

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