Reactome | PIK3CA M1043I [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PIK3CA M1043I [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19
crossReference	[DatabaseIdentifier:2395927] COSMIC:COSV55878974 [DatabaseIdentifier:2395928] COSMIC:COSV55873376 [DatabaseIdentifier:2395939] COSMIC:COSV55898229
dbId	1500719
disease	[Disease:1248674] large intestine cancer [Disease:1500689] cancer [Disease:1655470] thyroid cancer [Disease:1247632] glioblastoma multiforme [Disease:2317358] endometrial cancer [Disease:1614672] cervical cancer [Disease:1493885] bladder carcinoma [Disease:1500699] lung cancer [Disease:1500575] ovarian cancer [Disease:1500576] breast cancer
displayName	PIK3CA M1043I [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:1500708] L-methionine 1043 replaced with L-isoleucine
inDisease	true
literatureReference	[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers [LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399642] Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases
memberOf	[CandidateSet:R-HSA-2399596] PIK3CA kinase domain mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	PIK3CA M1043I PIK3CA Met1043Ile
referenceEntity	[ReferenceGeneProduct:61074] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1500719
startCoordinate	1
summation	[Summation:2399646] Substitution of methionine residue with isoleucine at positi...

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[CandidateSet:R-HSA-2399596] PIK3CA kinase domain mutants [cytosol]