Reactome | Formation of the MCC complex

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Formation of the MCC complex Show undefined attributes

authored	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
dbId	141437
displayName	Formation of the MCC complex
eventOf	[Pathway:R-HSA-141430] Inactivation of APC/C via direct inhibition of the APC/C complex - Homo sapiens
followingEvent	[Reaction:R-HSA-141423] Binding of the MCC complex to the APC/C complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-141447] Activated MAD2L1 [cytosol] [EntityWithAccessionedSequence:R-HSA-141436] BUB1B [cytosol] [EntityWithAccessionedSequence:R-HSA-141416] BUB3 [cytosol] [EntityWithAccessionedSequence:R-HSA-141412] CDC20 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:143450] Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Formation of the MCC complex
negativePrecedingEvent	[NegativePrecedingEvent:9766471] Futile Cycle: SCF-mediated degradation of Emi1
orthologousEvent	[Reaction:R-SCE-141437] Formation of the MCC complex - Saccharomyces cerevisiae [Reaction:R-SPO-141437] Formation of the MCC complex - Schizosaccharomyces pombe [Reaction:R-DDI-141437] Formation of the MCC complex - Dictyostelium discoideum [Reaction:R-CEL-141437] Formation of the MCC complex - Caenorhabditis elegans [Reaction:R-DME-141437] Formation of the MCC complex - Drosophila melanogaster [Reaction:R-GGA-141437] Formation of the MCC complex - Gallus gallus [Reaction:R-XTR-141437] Formation of the MCC complex - Xenopus tropicalis [Reaction:R-DRE-141437] Formation of the MCC complex - Danio rerio [Reaction:R-SSC-141437] Formation of the MCC complex - Sus scrofa [Reaction:R-BTA-141437] Formation of the MCC complex - Bos taurus [Reaction:R-CFA-141437] Formation of the MCC complex - Canis familiaris [Reaction:R-MMU-141437] Formation of the MCC complex - Mus musculus
output	[Complex:R-HSA-141440] hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol]
precedingEvent	[Reaction:R-HSA-141439] Release of activated MAD2 from kinetochores - Homo sapiens
releaseDate	2005-02-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-141437
summation	[Summation:141415] Upon release from the kinetochore, Mad2 associates with Cdc2...

Referrals

(hasEvent)	[Pathway:R-HSA-141430] Inactivation of APC/C via direct inhibition of the APC/C complex
(precedingEvent)	[Reaction:R-HSA-141423] Binding of the MCC complex to the APC/C complex