Reactome | Inactivation of APC/C via CDC20 sequestration

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Inactivation of APC/C via CDC20 sequestration Show undefined attributes

authored	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
dbId	141429
displayName	Inactivation of APC/C via CDC20 sequestration
edited	[InstanceEdit:174353] Matthews, L, 2006-02-17 05:19:32
eventOf	[Pathway:R-HSA-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-141447] Activated MAD2L1 [cytosol] [EntityWithAccessionedSequence:R-HSA-141412] CDC20 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:143447] The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Inactivation of APC/C via CDC20 sequestration
negativePrecedingEvent	[NegativePrecedingEvent:9766470] Futile Cycle: SCF-mediated degradation of Emi1
orthologousEvent	[Reaction:R-SCE-141429] Inactivation of APC/C via CDC20 sequestration - Saccharomyces cerevisiae [Reaction:R-SPO-141429] Inactivation of APC/C via CDC20 sequestration - Schizosaccharomyces pombe [Reaction:R-DDI-141429] Inactivation of APC/C via CDC20 sequestration - Dictyostelium discoideum [Reaction:R-CEL-141429] Inactivation of APC/C via CDC20 sequestration - Caenorhabditis elegans [Reaction:R-DME-141429] Inactivation of APC/C via CDC20 sequestration - Drosophila melanogaster [Reaction:R-GGA-141429] Inactivation of APC/C via CDC20 sequestration - Gallus gallus [Reaction:R-XTR-141429] Inactivation of APC/C via CDC20 sequestration - Xenopus tropicalis [Reaction:R-DRE-141429] Inactivation of APC/C via CDC20 sequestration - Danio rerio [Reaction:R-SSC-141429] Inactivation of APC/C via CDC20 sequestration - Sus scrofa [Reaction:R-BTA-141429] Inactivation of APC/C via CDC20 sequestration - Bos taurus [Reaction:R-CFA-141429] Inactivation of APC/C via CDC20 sequestration - Canis familiaris [Reaction:R-RNO-141429] Inactivation of APC/C via CDC20 sequestration - Rattus norvegicus [Reaction:R-MMU-141429] Inactivation of APC/C via CDC20 sequestration - Mus musculus
output	[Complex:R-HSA-141408] MAD2*CDC20 complex [cytosol]
precedingEvent	[Reaction:R-HSA-141439] Release of activated MAD2 from kinetochores - Homo sapiens
releaseDate	2005-02-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-141429
summation	[Summation:141414] In the sequestration model, the Mad2 molecules that dissoci...
updateTrackers	[UpdateTracker:9781443] Update Tracker - [Reaction:141429] Inactivation of APC/C via CDC20 sequestration - v61:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9781443] Update Tracker - [Reaction:141429] Inactivation of APC/C via CDC20 sequestration - v61:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

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