Reactome | PGG2 is reduced to PGH2 by PTGS1

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PGG2 is reduced to PGH2 by PTGS1 Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:140358] peroxidase activity of PTGS1 dimer [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9915548] peroxidase activity of PTGS1 dimer [endoplasmic reticulum membrane] Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:140352] Jassal, B, 2004-08-13 10:35:27
crossReference	[DatabaseIdentifier:12668318] RHEA:42601 [DatabaseIdentifier:9915541] RHEA:42600
dbId	140359
displayName	PGG2 is reduced to PGH2 by PTGS1
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-140180] COX reactions - Homo sapiens [Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Homo sapiens
followingEvent	[Reaction:R-HSA-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1 - Homo sapiens [Reaction:R-HSA-2161620] PGH2 is isomerised to PGD2 by PTGDS - Homo sapiens [BlackBoxEvent:R-HSA-2299725] PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol - Homo sapiens [Reaction:R-HSA-76500] TBXAS1 isomerises PGH2 to TXA2 - Homo sapiens [Reaction:R-HSA-76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 - Homo sapiens
input	[SimpleEntity:R-ALL-9915557] hydrogen donor [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-140357] PGG2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140567] Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis [LiteratureReference:2162129] Human cyclooxygenase-2 cDNA [LiteratureReference:2162103] Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid [LiteratureReference:2162150] Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PGG2 is reduced to PGH2 by PTGS1 AH2 + prostaglandin G2 = A + H2O + prostaglandin H2 Peroxidative reduction of PGG2 to PGH2
orthologousEvent	[Reaction:R-GGA-140359] PGG2 is reduced to PGH2 by PTGS1 - Gallus gallus [Reaction:R-XTR-140359] PGG2 is reduced to PGH2 by PTGS1 - Xenopus tropicalis [Reaction:R-DRE-140359] PGG2 is reduced to PGH2 by PTGS1 - Danio rerio [Reaction:R-SSC-140359] PGG2 is reduced to PGH2 by PTGS1 - Sus scrofa [Reaction:R-BTA-140359] PGG2 is reduced to PGH2 by PTGS1 - Bos taurus [Reaction:R-CFA-140359] PGG2 is reduced to PGH2 by PTGS1 - Canis familiaris [Reaction:R-RNO-140359] PGG2 is reduced to PGH2 by PTGS1 - Rattus norvegicus [Reaction:R-MMU-140359] PGG2 is reduced to PGH2 by PTGS1 - Mus musculus
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-9915551] hydrogen acceptor [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-30138] PGH2 [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-140355] Arachidonate is oxidised to PGG2 by PTGS1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-140359
summation	[Summation:179032] Prostaglandin G/H synthase 1 (PTGS1) exhibits a dual catalyt...
updateTrackers	[UpdateTracker:9791924] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v25:[modifyText] [UpdateTracker:9788652] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v41:[addInput, addLiteratureReference, modifyText] [UpdateTracker:9919391] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v90:[add_removeInput, removeOutput] [UpdateTracker:9788332] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v42:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791924] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v25:[modifyText] [UpdateTracker:9788652] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v41:[addInput, addLiteratureReference, modifyText] [UpdateTracker:9919391] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v90:[add_removeInput, removeOutput] [UpdateTracker:9788332] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v42:[modifyText]
(precedingEvent)	[Reaction:R-HSA-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1 [Reaction:R-HSA-2161620] PGH2 is isomerised to PGD2 by PTGDS [BlackBoxEvent:R-HSA-2299725] PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol [Reaction:R-HSA-76500] TBXAS1 isomerises PGH2 to TXA2 [Reaction:R-HSA-76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2
(hasEvent)	[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) [Pathway:R-HSA-140180] COX reactions

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