PGG2 is reduced to PGH2 by PTGS1

Stable Identifier
R-HSA-140359
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Peroxidative reduction of PGG2 to PGH2
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Prostaglandin G/H synthase 1 (PTGS1) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).

Literature References
PubMed ID Title Journal Year
7947975 Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

Barnett, J, Chow, J, Ives, D, Chiou, M, Mackenzie, R, Osen, E, Nguyen, B, Tsing, S, Bach, C, Freire, J

Biochim Biophys Acta 1994
9139685 Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid

Swinney, DC, Mak, AY, Barnett, J, Ramesha, CS

J Biol Chem 1997
4514999 Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis

Hamberg, M, Samuelsson, B

Proc Natl Acad Sci U S A 1973
1380156 Human cyclooxygenase-2 cDNA

Hla, T, Neilson, K

Proc Natl Acad Sci U S A 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peroxidase activity of PTGS1 dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created