PGG2 is reduced to PGH2 by PTGS1

Stable Identifier
R-HSA-140359
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
Synonyms
Peroxidative reduction of PGG2 to PGH2
ReviewStatus
5/5
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PGG2 is reduced to PGH2 by PTGS1
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Prostaglandin G/H synthase 1 (PTGS1) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).
Literature References
PubMed ID Title Journal Year
9139685 Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid

Mak, AY, Ramesha, CS, Swinney, DC, Barnett, J

J Biol Chem 1997
7947975 Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

Osen, E, Chow, J, Chiou, M, Mackenzie, R, Bach, C, Tsing, S, Freire, J, Ives, D, Barnett, J, Nguyen, B

Biochim Biophys Acta 1994
4514999 Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis

Hamberg, M, Samuelsson, B

Proc Natl Acad Sci U S A 1973
1380156 Human cyclooxygenase-2 cDNA

Hla, T, Neilson, K

Proc Natl Acad Sci U S A 1992
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peroxidase activity of PTGS1 dimer [endoplasmic reticulum membrane]

Physical Entity
PTGS1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
peroxidase activity (GO:0004601)
Orthologous Events
PGG2 is reduced to PGH2 by PTGS1 (Bos taurus)
PGG2 is reduced to PGH2 by PTGS1 (Canis familiaris)
PGG2 is reduced to PGH2 by PTGS1 (Danio rerio)
PGG2 is reduced to PGH2 by PTGS1 (Gallus gallus)
PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)
PGG2 is reduced to PGH2 by PTGS1 (Rattus norvegicus)
PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)
PGG2 is reduced to PGH2 by PTGS1 (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
Rush, MG  (2012-11-10)
Created
Jassal, B  (2004-08-13)
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