Reactome | Phosphorylation of DLC2 by MAPK8

Schema > Reaction > Entries

Phosphorylation of DLC2 by MAPK8 Show undefined attributes

catalystActivity	[CatalystActivity:140204] protein serine/threonine kinase activity of MAPK8 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
dbId	139908
displayName	Phosphorylation of DLC2 by MAPK8
eventOf	[Pathway:R-HSA-139910] Activation of BMF and translocation to mitochondria - Homo sapiens
followingEvent	[Reaction:R-HSA-139909] Translocation of BMF to mitochondria - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-140528] BMF sequestered to dynein (DLC2) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140440] JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation of DLC2 by MAPK8
orthologousEvent	[Reaction:R-GGA-139908] Phosphorylation of DLC2 by MAPK8 - Gallus gallus [Reaction:R-SSC-139908] Phosphorylation of DLC2 by MAPK8 - Sus scrofa [Reaction:R-BTA-139908] Phosphorylation of DLC2 by MAPK8 - Bos taurus [Reaction:R-CFA-139908] Phosphorylation of DLC2 by MAPK8 - Canis familiaris [Reaction:R-RNO-139908] Phosphorylation of DLC2 by MAPK8 - Rattus norvegicus [Reaction:R-MMU-139908] Phosphorylation of DLC2 by MAPK8 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-140530] Dynein (DLC2) on microtubules [plasma membrane] [EntityWithAccessionedSequence:R-HSA-140529] p-BMF [cytosol]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:3145024] Orlic-Milacic, M, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-139908
summation	[Summation:179064] MAPK8 (JNK) phosphorylates BMF on a DLC binding motif DKATQT...
updateTrackers	[UpdateTracker:9779241] Update Tracker - [Reaction:139908] Phosphorylation of DLC2 by MAPK8 - v66:[addInput, addOutput] [UpdateTracker:9788009] Update Tracker - [Reaction:139908] Phosphorylation of DLC2 by MAPK8 - v44:[add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779241] Update Tracker - [Reaction:139908] Phosphorylation of DLC2 by MAPK8 - v66:[addInput, addOutput] [UpdateTracker:9788009] Update Tracker - [Reaction:139908] Phosphorylation of DLC2 by MAPK8 - v44:[add_removeOutput, modifyText]
(precedingEvent)	[Reaction:R-HSA-139909] Translocation of BMF to mitochondria
(hasEvent)	[Pathway:R-HSA-139910] Activation of BMF and translocation to mitochondria