Phosphorylation of DLC2 by MAPK8

Stable Identifier
R-HSA-139908
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MAPK8 (JNK) phosphorylates BMF on a DLC binding motif DKATQTLSP involved in interaction with dynein DYNLL2 (DLC2), which sequesters BMF to the cytoskeleton. Phosphorylated BMF dissociates from dynein. Two JNK consensus sites exist in BMF: S74 and S77 (Lei and Davis 2003).
Literature References
PubMed ID Title Journal Year
12591950 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

Davis, RJ, Lei, K

Proc Natl Acad Sci U S A 2003
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of MAPK8 [cytosol]

Orthologous Events
Created
Cite Us!