Phosphorylation of DLC2 by MAPK8

Stable Identifier
R-HSA-139908
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAPK8 (JNK) phosphorylates BMF on a DLC binding motif DKATQTLSP involved in interaction with dynein DYNLL2 (DLC2), which sequesters BMF to the cytoskeleton. Phosphorylated BMF dissociates from dynein. Two JNK consensus sites exist in BMF: S74 and S77 (Lei and Davis 2003).

Literature References
PubMed ID Title Journal Year
12591950 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

Lei, K, Davis, RJ

Proc Natl Acad Sci U S A 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of MAPK8 [cytosol]
Physical Entity
Activity
Orthologous Events
Created