Reactome | Activation of TWIK-related K+ channel (TREK)

Schema > Reaction > Entries

Activation of TWIK-related K+ channel (TREK) Show undefined attributes

authored	[InstanceEdit:1296023] Mahajan, SS, 2011-05-18
catalystActivity	[CatalystActivity:1299262] potassium channel activity of TREK homodimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1296347] Mahajan, SS, 2011-05-19
crossReference	[DatabaseIdentifier:12667477] RHEA:29463
dbId	1296348
displayName	Activation of TWIK-related K+ channel (TREK)
edited	[InstanceEdit:1299538] Mahajan, SS, 2011-05-23
eventOf	[Pathway:R-HSA-1299503] TWIK related potassium channel (TREK) - Homo sapiens
input	[SimpleEntity:R-ALL-29804] K+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1296376] Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain [LiteratureReference:1296390] Task2 potassium channels set central respiratory CO2 and O2 sensitivity [LiteratureReference:1296362] AMP-activated protein kinase inhibits TREK channels [LiteratureReference:1296375] Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Activation of TWIK-related K+ channel (TREK)
orthologousEvent	[Reaction:R-SCE-1296348] Activation of TWIK-related K+ channel (TREK) - Saccharomyces cerevisiae [Reaction:R-CEL-1296348] Activation of TWIK-related K+ channel (TREK) - Caenorhabditis elegans [Reaction:R-DME-1296348] Activation of TWIK-related K+ channel (TREK) - Drosophila melanogaster [Reaction:R-GGA-1296348] Activation of TWIK-related K+ channel (TREK) - Gallus gallus [Reaction:R-XTR-1296348] Activation of TWIK-related K+ channel (TREK) - Xenopus tropicalis [Reaction:R-DRE-1296348] Activation of TWIK-related K+ channel (TREK) - Danio rerio [Reaction:R-SSC-1296348] Activation of TWIK-related K+ channel (TREK) - Sus scrofa [Reaction:R-BTA-1296348] Activation of TWIK-related K+ channel (TREK) - Bos taurus [Reaction:R-CFA-1296348] Activation of TWIK-related K+ channel (TREK) - Canis familiaris [Reaction:R-RNO-1296348] Activation of TWIK-related K+ channel (TREK) - Rattus norvegicus [Reaction:R-MMU-1296348] Activation of TWIK-related K+ channel (TREK) - Mus musculus
output	[SimpleEntity:R-ALL-74126] K+ [extracellular region]
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:975369] Jassal, Bijay, 2010-09-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1296348
summation	[Summation:1299363] TREK channels are activated by mechanical stretch, pH temper...

Referrals

(hasEvent)

[Pathway:R-HSA-1299503] TWIK related potassium channel (TREK)