Reactome | Activation of TWIK-related K+ channel (TREK)

Activation of TWIK-related K+ channel (TREK)

Stable Identifier

R-HSA-1296348

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Activation of TWIK-related K+ channel (TREK)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TREK channels are activated by mechanical stretch, pH temperature and arachidonic acid which leads to efflux of K+ into the extracellular space resulting in membrane hyperpolarization.

Literature References

PubMed ID	Title	Journal	Year
20410120	Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain Toyoda, H, Saito, M, Okazawa, M, Hirao, K, Sato, H, Abe, H, Takada, K, Funabiki, K, Takada, M, Kaneko, T, Kang, Y	J Neurosci	2010
19840997	AMP-activated protein kinase inhibits TREK channels Kréneisz, O, Benoit, JP, Bayliss, DA, Mulkey, DK	J Physiol	2009
20133877	Task2 potassium channels set central respiratory CO2 and O2 sensitivity Gestreau, C, Heitzmann, D, Thomas, J, Dubreuil, V, Bandulik, S, Reichold, M, Bendahhou, S, Pierson, P, Sterner, C, Peyronnet-Roux, J, Benfriha, C, Tegtmeier, I, Ehnes, H, Georgieff, M, Lesage, F, Brunet, JF, Goridis, C, Warth, R, Barhanin, J	Proc Natl Acad Sci U S A	2010
19536465	Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase Dallas, ML, Scragg, JL, Wyatt, CN, Ross, F, Hardie, DG, Evans, AM, Peers, C	Adv Exp Med Biol	2009