Activation of TWIK-related K+ channel (TREK)

Stable Identifier
R-HSA-1296348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TREK channels are activated by mechanical stretch, pH temperature and arachidonic acid which leads to efflux of K+ into the extracellular space resulting in membrane hyperpolarization.

Literature References
PubMed ID Title Journal Year
19840997 AMP-activated protein kinase inhibits TREK channels

Kréneisz, O, Benoit, JP, Bayliss, DA, Mulkey, DK

J Physiol 2009
20410120 Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain

Toyoda, H, Saito, M, Okazawa, M, Hirao, K, Sato, H, Abe, H, Takada, K, Funabiki, K, Takada, M, Kaneko, T, Kang, Y

J Neurosci 2010
20133877 Task2 potassium channels set central respiratory CO2 and O2 sensitivity

Gestreau, C, Heitzmann, D, Thomas, J, Dubreuil, V, Bandulik, S, Reichold, M, Bendahhou, S, Pierson, P, Sterner, C, Peyronnet-Roux, J, Benfriha, C, Tegtmeier, I, Ehnes, H, Georgieff, M, Lesage, F, Brunet, JF, Goridis, C, Warth, R, Barhanin, J

Proc Natl Acad Sci U S A 2010
19536465 Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase

Dallas, ML, Scragg, JL, Wyatt, CN, Ross, F, Hardie, DG, Evans, AM, Peers, C

Adv Exp Med Biol 2009
Participants
Input
Participates
Catalyst Activity

potassium channel activity of TREK homodimers [plasma membrane]

Orthologous Events
Cross References
Rhea
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