Activation of TWIK-related K+ channel (TREK)

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
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TREK channels are activated by mechanical stretch, pH temperature and arachidonic acid which leads to efflux of K+ into the extracellular space resulting in membrane hyperpolarization.

Literature References
PubMed ID Title Journal Year
20410120 Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain

Kaneko, T, Takada, K, Abe, H, Toyoda, H, Sato, H, Funabiki, K, Kang, Y, Takada, M, Okazawa, M, Saito, M, Hirao, K

J Neurosci 2010
19840997 AMP-activated protein kinase inhibits TREK channels

Kréneisz, O, Bayliss, DA, Benoit, JP, Mulkey, DK

J Physiol 2009
20133877 Task2 potassium channels set central respiratory CO2 and O2 sensitivity

Pierson, P, Ehnes, H, Warth, R, Benfriha, C, Bendahhou, S, Heitzmann, D, Goridis, C, Sterner, C, Dubreuil, V, Reichold, M, Gestreau, C, Tegtmeier, I, Bandulik, S, Georgieff, M, Lesage, F, Barhanin, J, Brunet, JF, Thomas, J, Peyronnet-Roux, J

Proc Natl Acad Sci U S A 2010
19536465 Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase

Ross, F, Evans, AM, Wyatt, CN, Hardie, DG, Scragg, JL, Peers, C, Dallas, ML

Adv Exp Med Biol 2009
Catalyst Activity

potassium channel activity of TREK homodimers [plasma membrane]

Orthologous Events
Cross References
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