Reactome | SRC phosphorylates SPRY2 on Y55 and Y227

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SRC phosphorylates SPRY2 on Y55 and Y227 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:179862] protein tyrosine kinase activity of SRC-1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1295600] Rothfels, K, 2011-05-17
dbId	1295609
displayName	SRC phosphorylates SPRY2 on Y55 and Y227
eventOf	[Pathway:R-HSA-1295596] Spry regulation of FGF signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-1295613] SPRY2 binds GRB2 - Homo sapiens [Reaction:R-HSA-1295622] SPRY2 binds CBL - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-934550] PP2A(A:C):SPRY2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:188712] FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity [LiteratureReference:1268103] Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function [LiteratureReference:934625] Phosphorylation of carboxyl-terminal tyrosines modulates the specificity of Sprouty-2 inhibition of different signaling pathways [LiteratureReference:188721] Regulation of sprouty stability by Mnk1-dependent phosphorylation
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	SRC phosphorylates SPRY2 on Y55 and Y227
orthologousEvent	[Reaction:R-MMU-1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - Mus musculus [Reaction:R-XTR-1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - Xenopus tropicalis [Reaction:R-DRE-1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - Danio rerio [Reaction:R-SSC-1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - Sus scrofa [Reaction:R-BTA-1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - Bos taurus [Reaction:R-CFA-1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - Canis familiaris [Reaction:R-RNO-1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-934598] PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1295599] SPRY2 translocates to the plasma membrane - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1295631] Negative regulation by 'PP2A(A:C):S112/S121-pSPRY2 [plasma membrane]'
regulationReference	[RegulationReference:9642765] Negative regulation by 'PP2A(A:C):S112/S121-pSPRY2 [plasma membrane]' Regulation of sprouty stability by Mnk1-dependent phosphorylation
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1295609
summation	[Summation:1295612] Sprouty 2 protein is phosphorylated on tyrosine residue 55. ...
updateTrackers	[UpdateTracker:9864352] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v88:[add_removeLiteratureReference, modifyText] [UpdateTracker:9775899] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v78:[modifyText] [UpdateTracker:9776162] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v77:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864352] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v88:[add_removeLiteratureReference, modifyText] [UpdateTracker:9775899] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v78:[modifyText] [UpdateTracker:9776162] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v77:[modifyText]
(hasEvent)	[Pathway:R-HSA-1295596] Spry regulation of FGF signaling
(precedingEvent)	[Reaction:R-HSA-1295613] SPRY2 binds GRB2 [Reaction:R-HSA-1295622] SPRY2 binds CBL

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