Reactome | Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton

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Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton Show undefined attributes

authored	[InstanceEdit:1237008] May, B, 2011-03-24
catalystActivity	[CatalystActivity:1237060] carbonate dehydratase activity of CA6:Zinc [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1237041] May, B, 2011-03-30
crossReference	[DatabaseIdentifier:12668149] RHEA:10750
dbId	1237045
displayName	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton
edited	[InstanceEdit:1237008] May, B, 2011-03-24
eventOf	[Pathway:R-HSA-1475029] Reversible hydration of carbon dioxide - Homo sapiens
input	[SimpleEntity:R-ALL-1237009] CO2 [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1237504] Gustin from human parotid saliva is carbonic anhydrase VI [LiteratureReference:1237473] Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines [LiteratureReference:1237495] Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors [LiteratureReference:1243058] Structure and mechanism of carbonic anhydrase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton H2O + CO2 -> H+ + HCO3-
orthologousEvent	[Reaction:R-GGA-1237045] Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton - Gallus gallus [Reaction:R-DRE-1237045] Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton - Danio rerio [Reaction:R-SSC-1237045] Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton - Sus scrofa [Reaction:R-BTA-1237045] Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton - Bos taurus [Reaction:R-CFA-1237045] Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton - Canis familiaris [Reaction:R-RNO-1237045] Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton - Rattus norvegicus [Reaction:R-MMU-1237045] Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton - Mus musculus
output	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-425425] HCO3- [extracellular region]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2252565] Jassal, B, 2012-05-16 [InstanceEdit:2252567] Silverman, DN, 2012-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1237045
summation	[Summation:1244345] Carbonic anhydrase VI (CA6) hydrates carbon dioxide to yield...

Referrals

(hasEvent)	[Pathway:R-HSA-1475029] Reversible hydration of carbon dioxide
(reverseReaction)	[Reaction:R-HSA-1237081] Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide

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