Reactome | Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton

Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton

Stable Identifier

R-HSA-1237045

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

H2O + CO2 -> H+ + HCO3-

ReviewStatus

5/5

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Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton

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Carbonic anhydrase VI (CA6) hydrates carbon dioxide to yield bicarbonate and a proton (Thatcher et al. 1998, Nishimori et al. 2007).Carbonic anhydrase deprotonates water to yield a zinc-hydroxyl group and a proton which is transferred to external buffer molecules via histidine or glutamate residues in carbonic anhydrase. The hydroxyl group reacts with carbon dioxide in the active site to yield bicarbonate. A water molecule displaces the bicarbonate and the reaction cycle begins again (reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible. CA6 is a major protein of saliva and is also known as gustin.

Literature References

PubMed ID	Title	Journal	Year
17228881	Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors Nishimori, I, Minakuchi, T, Onishi, S, Vullo, D, Scozzafava, A, Supuran, CT	J Med Chem	2007
17499996	Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines Nishimori, I, Onishi, S, Vullo, D, Innocenti, A, Scozzafava, A, Supuran, CT	Bioorg Med Chem	2007
9784398	Gustin from human parotid saliva is carbonic anhydrase VI Thatcher, BJ, Doherty, AE, Orvisky, E, Martin, BM, Henkin, RI	Biochem Biophys Res Commun	1998
9336012	Structure and mechanism of carbonic anhydrase Lindskog, S	Pharmacol Ther	1997