Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton

Stable Identifier
Reaction [transition]
Homo sapiens
H2O + CO2 -> H+ + HCO3-
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Carbonic anhydrase VI (CA6) hydrates carbon dioxide to yield bicarbonate and a proton (Thatcher et al. 1998, Nishimori et al. 2007).Carbonic anhydrase deprotonates water to yield a zinc-hydroxyl group and a proton which is transferred to external buffer molecules via histidine or glutamate residues in carbonic anhydrase. The hydroxyl group reacts with carbon dioxide in the active site to yield bicarbonate. A water molecule displaces the bicarbonate and the reaction cycle begins again (reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible. CA6 is a major protein of saliva and is also known as gustin.

Literature References
PubMed ID Title Journal Year
17228881 Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors

Nishimori, I, Supuran, CT, Scozzafava, A, Vullo, D, Onishi, S, Minakuchi, T

J Med Chem 2007
17499996 Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines

Innocenti, A, Nishimori, I, Supuran, CT, Scozzafava, A, Vullo, D, Onishi, S

Bioorg Med Chem 2007
9784398 Gustin from human parotid saliva is carbonic anhydrase VI

Martin, BM, Orvisky, E, Doherty, AE, Henkin, RI, Thatcher, BJ

Biochem Biophys Res Commun 1998
9336012 Structure and mechanism of carbonic anhydrase

Lindskog, S

Pharmacol Ther 1997
Catalyst Activity

carbonate dehydratase activity of CA6:Zinc [extracellular region]

Orthologous Events
Cross References
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